PIK3R6
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Official Full Name
phosphoinositide-3-kinase, regulatory subunit 6 -
Synonyms
RGD1560850
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PIK3R6-1059H | Recombinant Human PIK3R6 | Mammalian Cells | Human | His |
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| PIK3R6-3863H | Recombinant Human PIK3R6 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| PIK3R6-3863H-B | Recombinant Human PIK3R6 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
PIK3R6 involved in several pathways and played different roles in them. We selected most pathways PIK3R6 participated on our site, such as 3-phosphoinositide biosynthesis,G beta:gamma signalling through PI3Kgamma,G-protein beta:gamma signalling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPVI-mediated activation cascade | RHOB,FCER1GL,RHOGA,PDPN,G6b,LCP2A,C6orf25,CLEC1B |
| Metabolism of lipids and lipoproteins | FABP1B.1,CYP2AD2,CYP2AD3,LBR,MED16,CLPS,ELOVL1A,MED29,CPNE3,CTGF |
| Metabolism | AK7A,SLCO1B1,ACOT6,SLC5A9,SLC25A11,PDP1,GGT6,TYMP,SLC4A1B,ESRRA |
| 3-phosphoinositide biosynthesis | PIP5KL1,FIG4,CDIPT |
| Hemostasis | PROCA,ANXA2,KCNMA1,HRG,MERTK,PDE10A,SLC16A1,DOCK9,GATA6,PLEK |
| GPCR downstream signaling | OXGR1A.2,PTHLH,ANXA1C,KISS1,CCL27,RGS1,FGD4A,PENKA,DGKQ,TRH |
Protein Function
PIK3R6 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity,contributes_to phosphatidylinositol-4,5-bisphosphate 3-kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R6 itself. We selected most functions PIK3R6 had, and list some proteins which have the same functions with PIK3R6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CHN2,MID2,RUNX3,PCMT1,HNRNPU,MAP3K4,PUF60,TRPC4,KCNIP2,GBP1 |
| 1-phosphatidylinositol-3-kinase regulator activity | CCKBR,PIK3R1,PIK3R3A,PIK3R3,PIK3R2,PIK3R5,PIK3R3B |
Interacting Protein
PIK3R6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R6.
PDE3B;RAPGEF3
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References
- Folgiero, V; Di Carlo, SE; et al. Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells. CELL DEATH & DISEASE 3:-(2012).
- Weinger, JG; Gohari, P; et al. In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation. JOURNAL OF NEUROCHEMISTRY 106:134-146(2008).
