PIGK

  • Official Full Name

    phosphatidylinositol glycan anchor biosynthesis, class K

  • Overview

    This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.

  • Synonyms

    PIGK;phosphatidylinositol glycan anchor biosynthesis, class K;phosphatidylinositol glycan, class K;GPI-anchor transamidase;GPI transamidase subunit;GPI8;hGPI8;PIG-K;GPI8 homolog;phosphatidylinositol-glycan biosynthesis class K protein;MGC22559

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Rhesus macaque
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PIGK-1706H Recombinant Human PIGK, His-tagged E.coli Human His N-term-332aa
PIGK-12781M Recombinant Mouse PIGK Protein Mammalian Cells Mouse His
PIGK-2935C Recombinant Chicken PIGK Mammalian Cells Chicken His
PIGK-3427R Recombinant Rhesus monkey PIGK Protein, His-tagged Mammalian Cells Rhesus macaque His
PIGK-373Z Recombinant Zebrafish PIGK Mammalian Cells Zebrafish His
PIGK-3197HCL Recombinant Human PIGK 293 Cell Lysate HEK293 Human Non
PIGK-3245R Recombinant Rhesus Macaque PIGK Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PIGK-3245R-B Recombinant Rhesus Macaque PIGK Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PIGK-6724M Recombinant Mouse PIGK Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PIGK-6724M-B Recombinant Mouse PIGK Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PIGK involved in several pathways and played different roles in them. We selected most pathways PIGK participated on our site, such as Attachment of GPI anchor to uPAR,Glycosylphosphatidylinositol(GPI)-anchor biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIGK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of proteins TRAPPC3,EIF2B1,THSD1,LTF,SLC35A1,ARSD,IGFBP2A,IGFBP2,ZNF408,ARL2
    Post-translational protein modification ALG14,ALG10B,BET1,SUMF2,ADAMTS18,B3GALTL,MIA3,CNIH3,ANKRD28,NSMCE2
    Metabolic pathways MTMR2,BPNT1,FUT9A,CYP2A4,GPAM,HSD3B5,CYP2P10,PCYT1BA,LAP3,NT5C2
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis PIGO,PIGH,GPAA1,PIGW,PIGC,PIGX,PIGN,PIGL,PIGP,PIGYL

    Protein Function

    PIGK has several biochemical functions, for example, contributes_to GPI anchor binding,GPI-anchor transamidase activity,cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIGK itself. We selected most functions PIGK had, and list some proteins which have the same functions with PIGK. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type peptidase activity CTSJ,CAPN2A,BLMH,FAM49BA,CASP7,CASP5,CASP3B,CTSBA,CASP8L1,CTSC
    protein binding FGFR1OP2,NEK8,NSMCE1,TNFAIP8,MCM2,PIN4,PITX1,CEP55,NPM1,RAB32
    contributes_to GPI anchor binding GPAA1
    protein disulfide isomerase activity QSOX2,PDIA2,GLRX2,ZNF169,TXNDC11,TMX4,PDIA4,PDIA3,PDIA6,PDIA5
    GPI-anchor transamidase activity NUDT13,FAM108B,FAM108C,PIGU,FAM108A,MBLAC1

    Interacting Protein

    PIGK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIGK here. Most of them are supplied by our site. Hope this information will be useful for your research of PIGK.

    ALPP;midostaurin;PIGS

    Resources

    Research Area

    CAR-T Cell Therapy Targets

    References

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