PIGC
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Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class C -
Overview
This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. -
Synonyms
PIGC;phosphatidylinositol glycan anchor biosynthesis, class C;phosphatidylinositol glycan, class C;phosphatidylinositol N-acetylglucosaminyltransferase subunit C;GPI2;Phosphatidylinositol glycan biosynthesis class C protein;Phosphatidylinositol N acetylglucosaminyltransferase subunit C;PIG-C;OTTHUMP00000032652;phosphatidylinositol-glycan biosynthesis class C protein;phosphatidylinositol-glycan biosynthesis, class C protein
Recombinant Proteins
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- Bovine
- Mus musculus
- Human
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- His&Fc&Avi
Involved Pathway
PIGC involved in several pathways and played different roles in them. We selected most pathways PIGC participated on our site, such as Glycosylphosphatidylinositol(GPI)-anchor biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIGC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | PIGA,PIGV,PIGM,PIGL,PIGZ,PIGF,PIGN,GPAA1,PIGU,PIGYL |
| Metabolic pathways | B3GALNT1,ALG6,CYP27B1,PLA2G12B,PTGS2B,COX5B,INPP5A,HSD3B7,NDST4,DUT |
Protein Function
PIGC has several biochemical functions, for example, 7S RNA binding,GDP binding,GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIGC itself. We selected most functions PIGC had, and list some proteins which have the same functions with PIGC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 7S RNA binding | SRP19,SRP54,EXOSC2,SRP72,SRP54A,SRP9,SRP14,SRP68 |
| ribonucleoprotein complex binding | PITX2,PRMT7,YBX2,IFIH1,SECISBP2,RNF135,PRPF31,PRPF6,PRMT5,UHMK1 |
| contributes_to GTPase activity | SRP54,SRP54B,SRP54A |
| poly(A) RNA binding | HMGB2,TNS1,LYAR,SRPK2,APEX1,SERBP1,MYO5A,FASTKD2,UBC,MECP2 |
| drug binding | SETD6,GPR30,ACE,ADRB2,PPARA,TLR7,HMGB2,DRD4,IL2RA,SRP54A |
| GTP binding | RND3A,GNAI1,TRIM66,MTIF2,ADSSL,DIRAS3,TUBB4B,EIF5,DRG1,GTPBP8 |
| endoplasmic reticulum signal peptide binding | SRP14,SRP54B,SRP54A,SRP68,SRP54 |
| GDP binding | GNAI1,MIEF1,RAB14,RAP2C,RAB9B,RAB7A,RAB12,TRIM23,RAB5C,RAB9A |
Interacting Protein
PIGC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIGC here. Most of them are supplied by our site. Hope this information will be useful for your research of PIGC.
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