PICK1
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Official Full Name
protein interacting with PRKCA 1 -
Overview
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. -
Synonyms
PICK1;protein interacting with PRKCA 1;PRKCABP, protein interacting with PRKCA , protein kinase C, alpha binding protein;PRKCA-binding protein;dJ1039K5;MGC15204;OTTHUMP00000028509;PICK 1;PICK1_HUMAN;PRKCA binding protein;PRKCABP;Protein interacting with C kinase 1;Protein interacting with PRKCA;Protein kinase C alpha binding protein;Protein kinase C-alpha-binding protein;Protein that interacts with C kinase 1;OTTHUMP00000199277;OTTHUMP00000199289;OTTHUMP00000199291;PICK
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&T7
- Non
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PICK1 involved in several pathways and played different roles in them. We selected most pathways PICK1 participated on our site, such as Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity,Neuronal System,Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with PICK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Trafficking of GluR2-containing AMPA receptors | GRIP1,HAND2 |
| Neuronal System | KCNJ1A.6,KCNMB1,ABCC9,KCNH1,SLC1A7A,KCNV1,KCNA6A,KCNC1,CPLX2L,CHRNB2 |
| Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | MYO6,AKAP5,CACNG2,CACNG3,HAND2,NSFB,GRIP1,NSFA |
| Transmission across Chemical Synapses | SLC1A2B,Apba1,CACFD1,RAB3AA,SLC6A11,ARL6IP5A,SLC1A2A,RAB3AB,PPFIA2,SYN2 |
| Trafficking of AMPA receptors | GRIP1,HAND2 |
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | CAMKK1B,CHRNA2,AKAP5,CHRNA5,GABRR2A,CHRND,HAND2,GRIP1,MYO6,NCALDA |
Protein Function
PICK1 has several biochemical functions, for example, ATPase activity,Arp2/3 complex binding,G-protein coupled receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PICK1 itself. We selected most functions PICK1 had, and list some proteins which have the same functions with PICK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Arp2/3 complex binding | HAND2,GMFG,SNX9,ARPC2,GMFB,WHAMM,CORO1B |
| receptor binding | P2RX7,CRTAM,BMP2,GSDMA2,ADAM10,CD86,FGG,VTCN1,SELPLG,PKD2 |
| metal ion binding | CLCA2,ZC3H18,GBGT1,ZFP13,ZNF486,CHN1,ZBTB12,DMPK,BTR06,HDAC8 |
| enzyme binding | Alb,PCCA,DDC,Ar,PDCD2,PGR,CAD,YWHAE,GNB2L1,GRIN1 |
| protein binding | TNS4,OTULIN,CRX,DTX1,KRT6B,CRY1,MAP4K2,NCK2,DIABLO,TALDO1 |
| protein kinase C binding | SQSTM1,IRS1,ADAM9,PKN1,PAWR,UGT1A7,TRPV4,PRKCB,SDC4,TOP2A |
| protein C-terminus binding | SDCBP,KPNA3,TRIM3,PROP1,SHANK1,VAMP2,PABPC1,CALCOCO1,HSPB7,NCL |
| actin filament binding | SVIL,CTNNA3,MYH11,VCLA,ANXA8,EZR,TMOD1,KLHL17,CORO1B,TRIOBP |
| protein domain specific binding | HIST1H4C,VAPA,WNT5A,PLXND1,HIST1H4I,KCNN2,CHMP1B,SCN5A,RQCD1,YWHAG |
Interacting Protein
PICK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PICK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PICK1.
ASIC1;SLC6A3;SLC6A2;ASIC2;PRLHR;ATXN7;PRKCG;SLC6A4;AKT1
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References
- Ramos, C; Chardonnet, S; et al. Native Presynaptic Metabotropic Glutamate Receptor 4 (mGluR4) Interacts with Exocytosis Proteins in Rat Cerebellum. JOURNAL OF BIOLOGICAL CHEMISTRY 287:20176-20186(2012).
- Selak, S; Paternain, AV; et al. A Role for SNAP25 in Internalization of Kainate Receptors and Synaptic Plasticity. NEURON 63:357-371(2009).
