PHYH
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Official Full Name
phytanoyl-CoA 2-hydroxylase -
Overview
PhyH is a peroxisomal protein that is involved in the alpha-oxidation of 3-methyl branched fatty acids. Specifically, this protein converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. It requires iron and ascorbate as cofactors and is expressed in liver, kid -
Synonyms
PHYH;phytanoyl-CoA 2-hydroxylase;phytanoyl CoA hydroxylase , phytanoyl CoA hydroxylase (Refsum disease);phytanoyl-CoA dioxygenase, peroxisomal;PAHX;PHYH1;phytanoyl CoA dioxygenase;RD;Refsum disease;phytanic acid oxidase;phytanoil-CoA alpha hydr
Recombinant Proteins
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- Human
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
PHYH involved in several pathways and played different roles in them. We selected most pathways PHYH participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHYH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | ACSL3,PXMP2,PRDX5,ECI2,SCP2A,PEX14,NUDT7,ACSL1,MVK,FAR2 |
Protein Function
PHYH has several biochemical functions, for example, L-ascorbic acid binding,cofactor binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHYH itself. We selected most functions PHYH had, and list some proteins which have the same functions with PHYH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ACSM3,CYP2AA6,PTGS1,LMAN2,ZMYND15,CYBA,NME6,PHF23A,RARAA,ZDHHC15A |
| protein binding | EYA2,ITGA7,SRI,QKI,VAV1,XCL2,NEU2,VSIG4,DTNB,BCL2L11 |
| cofactor binding | ASNS,DAO,PGAM2,ACLYA,UROS,TYMS,DDO,PAH,BIRC5,TKT |
| L-ascorbic acid binding | LEPRE1,P4HA1,FAM125B,PLOD3,EGLN1,OGFOD2,PLOD1,LEPREL2,ALKBH3,P4HTM |
Interacting Protein
PHYH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHYH here. Most of them are supplied by our site. Hope this information will be useful for your research of PHYH.
FAM9B;ABCD3;PTH2R;RNF167;WRAP73;COPS3;TOM1L1;MAGEA11
Resources
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References
- Araujo, WL; Ishizaki, K; et al. Analysis of a Range of Catabolic Mutants Provides Evidence That Phytanoyl-Coenzyme A Does Not Act as a Substrate of the Electron-Transfer Flavoprotein/Electron-Transfer Flavoprotein:Ubiquinone Oxidoreductase Complex in Arabidopsis during Dark-Induced Senescence. PLANT PHYSIOLOGY 157:55-69(2011).
- Wanders, RJA; Komen, J; et al. Phytanic acid metabolism in health and disease. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1811:498-507(2011).
