PHLPP1

  • Official Full Name

    PH domain and leucine rich repeat protein phosphatase 1

  • Overview

    PH domain and leucine rich repeat protein phosphatase, also known as PHLPP, is an enzyme which in humans is encoded by the PHLPP gene.

  • Synonyms

    PHLPP1;PH domain and leucine rich repeat protein phosphatase 1;PH domain and leucine rich repeat protein phosphatase , PHLPP, pleckstrin homology domain containing, family E (with leucine rich repeats) member 1 , PLEKHE1;PH domain leucine-rich repeat-containing protein phosphatase 1;KIAA0606;SCOP;hSCOP;PH domain and leucine rich repeat protein phosphatase;PH domain leucine rich repeat containing protein phosphatase;PH domain leucine rich repeat protein phosphatase;PH domain-containing family E member 1;PHLP1_HUMAN;Pleckstrin homology domain containing family E protein 1;Pleckstrin homology domain-containing family E member 1;PLEKHE 1 protein;SCN circadian oscillatory protein;SUPRACHIASMATIC NUCLEUS CIRCADIAN OSCILLATORY PROTEIN;Suprachiasmatic nucleus circadian protein;pleckstrin homology domain containing, family E (with leucine rich repeats) member 1;PHLPP;PLEKHE1

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Non
  • GST
  • His&Fc&Avi
  • Flag
  • Myc&DDK

    Involved Pathway

    PHLPP1 involved in several pathways and played different roles in them. We selected most pathways PHLPP1 participated on our site, such as PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHLPP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway ITGA3,LAMA4,FN1,PDGFA,FGF19,PDGFRB,LAMB2,THBS3,IL3,OSM

    Protein Function

    PHLPP1 has several biochemical functions, for example, metal ion binding,phosphoprotein phosphatase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHLPP1 itself. We selected most functions PHLPP1 had, and list some proteins which have the same functions with PHLPP1. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding PPP1R10,ZEB1B,SHHA,SMYD2B,SDF4,ZFC3H1,IKZF1,TRIM36,ATP8A1,ARSE
    protein binding DDA1,DPM2,C2orf57,EWSR1A,CD84,SELS,MTMR7,CLC,ABHD14B,HECTD3
    phosphoprotein phosphatase activity PTPRQ,PTPN11B,CTDSPL2,PPM1NB,PHPT1,CTDNEP1B,CDC25D,CDC14A,DUSP28,DUSP22B

    Interacting Protein

    PHLPP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHLPP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHLPP1.

    SCRIB;PRKCB;Rps6kb1;BRAP;USP12;USP1;PPP5C;USP46;DMWD;FKBP5

    Resources

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