PHKG2
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Official Full Name
phosphorylase kinase, gamma 2 (testis) -
Overview
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. -
Synonyms
PHKG2;phosphorylase kinase, gamma 2 (testis);phosphorylase b kinase gamma catalytic chain, testis/liver isoform;PSK-C3;PHK-gamma-T;phosphorylase kinase subunit gamma-2;serine/threonine-protein kinase PHKG2;Phosphorylase kinase, gamma 2 (testis/live
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Insect Cell
- Sf9 Insect Cell
- HEK293
- Insect (sf21)
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
PHKG2 involved in several pathways and played different roles in them. We selected most pathways PHKG2 participated on our site, such as Calcium signaling pathway,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHKG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin signaling pathway | INS,PRKAR2AA,RPTOR,BRAF,MAPK3,INSR,BADB,PIK3R3B,SOCS9,PCK2 |
| Calcium signaling pathway | SLC25A5,ERBB4A,PPP3CA,PDGFRA,ADRB3,PHKG1,PTGFR,RYR2,EGFRA,CAMK2D2 |
Protein Function
PHKG2 has several biochemical functions, for example, ATP binding,calmodulin binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHKG2 itself. We selected most functions PHKG2 had, and list some proteins which have the same functions with PHKG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | KCNN3,PHKG1A,CAMK2D2,DAPK2,MYO5A,GEM,CAMK4,CNN2,DCX,TRPM4 |
| tau-protein kinase activity | GSK3B,CSNK1D,MARK4,MARK2,PHKG1,CDK5,PRKAA1,MARK1,GSK3A |
| ATP binding | MST1R,CAD,RIOK3,TLK2,MYLK2,DHX30,OXSR1B,DDR1,UBE2K,DDX19A |
| protein serine/threonine kinase activity | WNK1,MELK,TAOK3,MAPK1,EIF2AK4,CASK,PLK2B,MAP3K10,NLK2,LIMK1 |
| enzyme binding | EGLN1,CUTA,MDM4,BCR,VAPB,HIST1H2AK,UGT1A6A,HIST1H2AM,RCOR2,HDAC3 |
| phosphorylase kinase activity | PHKA2,PHKG1A,PHKG1B,PHKG1,PHKB |
Interacting Protein
PHKG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHKG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHKG2.
PHKA2;disA;linkable sunitinib analogue;purvalanol b;PEX10;NDUFA4;GAK;SCO2;LAMC1;VDAC2;PHKA1;PHKA1;FASN;NPEPPS;HIST1H3D;PRKDC;ACACA;ATAD3C;CLASP1
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