PHC1

  • Official Full Name

    polyhomeotic homolog 1 (Drosophila)

  • Overview

    This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene;product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1.;The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named;homology domains I and II. These domains are involved in protein-protein interactions and may mediate;heterodimerization of the protein encoded by this gene and the EDR2 protein.

  • Synonyms

    PHC1;polyhomeotic homolog 1 (Drosophila);early development regulator 1 (homolog of polyhomeotic 1) , EDR1, polyhomeotic like 1 (Drosophila);polyhomeotic-like protein 1;HPH1;RAE28;Early development regulatory protein 1;EDR1 PH1;mPH1;PH1;OTTHUMP00000238481;OTTHUMP00000238482;OTTHUMP00000238483;polyhomeotic-like 1;early development regulator 1 (homolog of polyhomeotic 1);EDR1

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Rhesus macaque
  • E.coli
  • Mammalian Cell
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PHC1-1675H Recombinant Human PHC1, GST-tagged E.coli Human GST C-term-350aa
PHC1-11728Z Recombinant Zebrafish PHC1 Mammalian Cell Zebrafish His
PHC1-1396C Recombinant Chicken PHC1 Mammalian Cell Chicken His
PHC1-3402R Recombinant Rhesus monkey PHC1 Protein, His-tagged Mammalian Cell Rhesus macaque His
PHC1-3239HCL Recombinant Human PHC1 293 Cell Lysate HEK293 Human Non
PHC1-3220R Recombinant Rhesus Macaque PHC1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PHC1-3220R-B Recombinant Rhesus Macaque PHC1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    PHC1 involved in several pathways and played different roles in them. We selected most pathways PHC1 participated on our site, such as Cellular Senescence,Cellular responses to stress,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of proteins YIF1A,MUC20,NSMCE4A,SLC34A2A,IGFBP2,TRAPPC6B,PMPCB,MTX1,ZDHHC2,TIMM22
    Cellular responses to stress H1F0,CDKN2B,HIST1H1D,CBX6,TXN,EP400,PHC2,CBX8A,DPF1,CBX8
    SUMOylation SENP1,NSMCE4A,SAE1,PHC2,SCMH1,RNF2,NSMCE2,UBA2,SMC5,RING1
    Cellular Senescence HIST1H1B,SUZ12A,CBX6A,BMI1B,CEBPB,HIST1H1A,H3F3D,E2F2,TXN,MINK1
    Oxidative Stress Induced Senescence SUZ12,SUZ12B,RNF2,CBX6,SUZ12A,CBX8B,BMI1A,CBX6A,PHC2,PHC3
    SUMO E3 ligases SUMOylate target proteins PHC2,SCMH1,CBX4,PHC3,CBX8,SMC5,NSMCE1,RNF2,NSMCE4A,RING1
    SUMOylation of DNA damage response and repair proteins CBX8,SMC5,PHC3,EID3,NSMCE2,RNF2,SCMH1,PHC2,NSMCE1,NSMCE4A
    Post-translational protein modification TRAPPC2L,PPP6C,GNE,MPDU1B,MGAT4B,TRAPPC5,EID3,PREB,MPDU1,WDR85

    Protein Function

    PHC1 has several biochemical functions, for example, DNA binding,chromatin binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHC1 itself. We selected most functions PHC1 had, and list some proteins which have the same functions with PHC1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding POLR2B,RNF11,LBX1,SYCP2,HMGB2,SOX6,ZBED5,GM14483,TOX,ZFP526
    chromatin binding KDM1A,GATA2A,SP3,GATA2B,SIRT7,MPO,TSHZ3,MEF2C,DNMT3A,SHMT2
    zinc ion binding TRAIP,NR1H3,BTR22,TAB3,ZSWIM1,CPA5,RNF169,AJUBA,CPA2,LIMS1

    Interacting Protein

    PHC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHC1.

    CBX4;BMI1;PCGF2;CBX8;q81y32_bacan;HSPA8;PPP1CA;UBE2I;y2173_bacan;aadK;PHC2;SFMBT1;CBX4;Bmi1;Cbx2

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