PGM1
-
Official Full Name
phosphoglucomutase 1 -
Overview
The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene. -
Synonyms
PGM1;phosphoglucomutase 1;phosphoglucomutase-1;Glucose phosphomutase 1;GSD14;OTTHUMP00000010519;OTTHUMP00000010520;PGM 1;PGM1_HUMAN;Phosphoglucomutase1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Cynomolgus
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- Non
- His
- Myc&DDK
- His&Fc&Avi
- His&SUMO
- Flag
Involved Pathway
PGM1 involved in several pathways and played different roles in them. We selected most pathways PGM1 participated on our site, such as Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Galactose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PGM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | UGT1A6B,HSD17B12A,HYAL2,GBGT1L4,QPRT,ACER1,DAO.3,MINPP1,MTHFS,ACSM3 |
| Pentose phosphate pathway | FBP2,ALDOB,FBP1B,G6PDX,RBKS,RPIA,GPIB,ALDOA,ALDOC,PRPS1L1 |
| Glycolysis / Gluconeogenesis | PGAM1A,PDHB,ALDH3B2,ALDH9A1A.1,ALDH3B1,FBP1B,GALM,MINPP1,ENO1B,PFKM |
| Starch and sucrose metabolism | UGT2B15,AMY2B,GBA3,GPI,PYGM,GANC,UGT1A2,HK3,AGLA,GYS1 |
| Amino sugar and nucleotide sugar metabolism | GMPPAA,UGP2A,FPGT,CYB5R2,CHIA.3,CHIA.4,RENBP,GKUP,GALK1,CHIA.2 |
| Purine metabolism | RRM2,ADSL,PNP6,PDE6H,AK4,AMPD2,NT5C,POLR1A,NUDT16,PDE9A |
| Galactose metabolism | UGP2,B4GALT2,UGP2B,aLA,LCT,GALM,HK2,HK3,HK1,GALE |
Protein Function
PGM1 has several biochemical functions, for example, magnesium ion binding,phosphoglucomutase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PGM1 itself. We selected most functions PGM1 had, and list some proteins which have the same functions with PGM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphoglucomutase activity | PGM2,PGM3 |
| magnesium ion binding | NUDT7,AASDHPPT,HPRT1L,NIM1,ABL1,ADSSL1,ENOSF1,NT5C3B,HPRT1,PKMA |
| protein binding | CDC7,PDLIM5,SMAD3A,SLC1A1,CUTA,MAPK1,FZR1,CHAMP1,ITPKB,HIST1H4H |
Interacting Protein
PGM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PGM1.
TINF2;UBA5;KIF1B;DNAJB6;ENO3;TERF1;dAK1_1;POT1;TERF2IP
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References
- Berbic, M; Schulke, L; et al. Macrophage expression in endometrium of women with and without endometriosis. HUMAN REPRODUCTION 24:325-332(2009).
- Hata, S; Kanomata, N; et al. Cytologic Appearance of Myospherulosis of the Breast Diagnosed by Fine-Needle Aspirates: A Clinical, Cytological and Immunocytochemical Study of 23 Cases. DIAGNOSTIC CYTOPATHOLOGY 39:177-180(2011).
