PFKP
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Official Full Name
phosphofructokinase, platelet -
Overview
The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK);(ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of;fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which;maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM;171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) (PubMed;6451249) determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits;P4, P3L, and P2L2. -
Synonyms
PFKP;phosphofructokinase, platelet;6-phosphofructokinase type C;PFK C;PFKF;Phosphofructokinase;platelet type;phosphohexokinase;phosphofructokinase 1;phosphofructo-1-kinase isozyme C;Phosphofructokinase, platelet type;6-phosphofructokinase, plat
Recombinant Proteins
- Mouse
- Rat
- Human
- Chicken
- HEK293
- E.coli
- Mammalian Cells
- Insect Cells
- Myc&DDK
- His&T7
- His
- Non
- His&Fc&Avi
- Flag
- His&GST
Involved Pathway
PFKP involved in several pathways and played different roles in them. We selected most pathways PFKP participated on our site, such as Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFKP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pentose phosphate pathway | FBP1,PRPS2,FBP1B,PRPS1A,RGN,TKTL2,PGD,PFKMB,TKT,G6PD |
| Glycolysis / Gluconeogenesis | ENO2,ALDOCB,GPIB,PGK2,ACSS2,PDHA1A,ALDH2.1,ALDH2,DLAT,HKDC1 |
| Thyroid hormone signaling pathway | KAT2A,MTOR,ITGB3,PLN,CASP9,MED27,ATP1A3,PRKCA,NOTCH2,PIK3CB |
| AMPK signaling pathway | PPP2R5B,CREB3L2,AKT1,ADIPOR1,IRS1,PIK3R3,PPP2R2C,PFKFB1,MAP3K7,PRKAG3 |
| Carbon metabolism | PDHA1,H6PD,HK2,ACSS1,IDH3G,FBP1,TALDO1,GPT2,PDHB,IDH2 |
| Fructose and mannose metabolism | PFKFB1,ENOSF1,TPI1A,PFKMB,SORD,FBP1B,AKR1B1L,FBP2,PMM2,GMDS |
| Central carbon metabolism in cancer | PDK1,HK2,PDHA2,PDGFRB,MET,IDH1,PKM2,SCO2,PIK3CB,PDGFRA |
| Galactose metabolism | GALT,SI,AKR1B1,G6PC,G6PCA.1,HK1,AKR1B8,LCT,PGM1,GALE |
| Metabolic pathways | TK1,PAFAH1B1A,GKUP,ALOX12E,SMPD2,ACLYA,CYP27A1,ATP6V0CB,CKM,ALDH3A1 |
Protein Function
PFKP has several biochemical functions, for example, 6-phosphofructokinase activity,ATP binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFKP itself. We selected most functions PFKP had, and list some proteins which have the same functions with PFKP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | TUB,NRAS,CRIPT,ING2,PDCL,Cel,WASF1,TRAF2,CAPG,Casp3 |
| ATP binding | CHEK1,VMHC,STK25B,ENTPD8,CLCN7,RTEL1,EIF4A1,ACSM3,ATAD1A,NEK5 |
| metal ion binding | CYBASC3,FGD1,ZFP36L1A,RSAD2,Trf,TOE1,ADNP2,RAB11FIP4A,PVALB5,ITGAX |
| 6-phosphofructokinase activity | PFKMA,PFKMB,PFKLB,PFKL,PFKM |
Interacting Protein
PFKP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFKP here. Most of them are supplied by our site. Hope this information will be useful for your research of PFKP.
GBAS;BCAR3;TNFRSF1B;MCC;HLA-B;GABARAPL2;MAX;ARF6;YWHAZ;DMWD;GSTK1;PRKAB1;TRAF6;WIPI2;TERF1;ACD;TINF2;WNK1
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