PEX6
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Official Full Name
peroxisomal biogenesis factor 6 -
Overview
This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6. -
Synonyms
PEX6;peroxisomal biogenesis factor 6;peroxisome biogenesis factor 6;PAF 2;PXAAA1;PAF2;Peroxin 6;Peroxisomal AAA type ATPase 1;peroxin-6;peroxisomal-type ATPase 1;peroxisome assembly factor 2;peroxisomal AAA-type ATPase 1;PAF-2
Recombinant Proteins
- Arabidopsis thaliana
- Rat
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PEX6-1653A | Recombinant Arabidopsis thaliana PEX6, His-tagged | E.coli | Arabidopsis thaliana | His | 1-350aa | |
| PEX6-4387R | Recombinant Rat PEX6 Protein | Mammalian Cells | Rat | His |
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| PEX6-1067H | Recombinant Human PEX6 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| PEX6-4047R | Recombinant Rat PEX6 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| PEX6-4047R-B | Recombinant Rat PEX6 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Pex6-4801M | Recombinant Mouse Pex6 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| PEX6-686H | Recombinant Human PEX6 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
PEX6 involved in several pathways and played different roles in them. We selected most pathways PEX6 participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PEX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | ABCD3A,NOS2,CRATB,EPHX2,CRATA,GNPAT,IDH1,HAO2,PEX5L,PEX26 |
Protein Function
PEX6 has several biochemical functions, for example, ATP binding,ATPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEX6 itself. We selected most functions PEX6 had, and list some proteins which have the same functions with PEX6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DNAJA4,DDX39AA,ATP8A1,PIP5KL1,JAK3,MYO3B,PDPK1,DDX20,MYO1D,HSPA4A |
| ATPase activity | ABCG2A,HAND2,ABCA13,ATF7IP,ABCE1,HSPA5,ATAD2,ASNA1,ABCF2,ATAD1B |
| protein binding | NUP54,SULT1A1,EEF2,CD70,ALS2CR11,PDCL,BAD,BMP1,FEM1B,MED31 |
Interacting Protein
PEX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEX6.
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References
- Hashiguchi, N; Kojidani, T; et al. Peroxisomes are formed from complex membrane structures in PEX6-deficient CHO cells upon genetic complementation. MOLECULAR BIOLOGY OF THE CELL 13:711-722(2002).
- Faber, KN; Heyman, JA; et al. Two AAA family peroxins, PpPex1p and PpPex6p, interact with each other in an ATP-dependent manner and are associated with different subcellular membranous structures distinct from peroxisomes. MOLECULAR AND CELLULAR BIOLOGY 18:936-943(1998).
- Baker, A; Charlton, W; et al. Biochemical and molecular approaches to understanding protein import into peroxisomes. BIOCHEMICAL SOCIETY TRANSACTIONS 28:499-504(2000).
- Miyata, N; Okumoto, K; et al. AWP1/ZFAND6 Functions in Pex5 Export by Interacting with Cys-Monoubiquitinated Pex5 and Pex6 AAA ATPase. TRAFFIC 13:168-183(2012).
