PENK
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Official Full Name
proenkephalin -
Overview
Met-and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. -
Synonyms
Leu-enkephalin;Met-enkephalin;Met-enkephalin-Arg-Gly-Leu;Met-enkephalin-Arg-Phe;Methionine enkephalin;OGF;Opioid growth factor;PENK;PENK(114-133);PENK(143-183);PENK(237-258);PENK_HUMAN;PPA;Proenkephalin A;Proenkephalin;Proenkephalin-A;Synenkephalin;Met Enkephalin
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cells
- HEK293
- E.coli
- His
- His&T7
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
PENK involved in several pathways and played different roles in them. We selected most pathways PENK participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PENK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peptide ligand-binding receptors | INSL3,EDN3,CCL35.2,PENKB,PMCH,GAL,SSTR5,HEBP1,CX3CR1,CCBP2 |
| Signaling by GPCR | GPR55A,CCL35.2,RGS4,PENKA,GPR31,RGS10,NTS,TAAR1,ANXA1A,CXCR7B |
| G alpha (i) signalling events | RGS11,OPN1LW1,RHOL,SST1.1,OPN1SW1,CXCR7B,RGS18,ADORA1,RGS14,AGT |
| GPCR ligand binding | TAAR1,GHRH,RLN3,CCR7,ADCYAP1B,GPR39,CXCR7B,ADM,CNR1,CGA |
| Signal Transduction | SKILB,BOC,MYO9B,UCHL5,FST,CCL35.2,RLBP1A,RSPO1,FGFBP2,ADM |
| GPCR downstream signaling | PNOCB,GPR132B,NMS,RHOGA,CCR8,VIP,OPN1LW1,HCAR1-2,OPN1LW,PTHLHA |
| Class A/1 (Rhodopsin-like receptors) | OPN5,OPN4B,DRD3,CCL35.2,QRFP,NPFFR2,CCL35.1,KEL,TAC3,ADRA2A |
Protein Function
PENK has several biochemical functions, for example, neuropeptide hormone activity,opioid peptide activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PENK itself. We selected most functions PENK had, and list some proteins which have the same functions with PENK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| neuropeptide hormone activity | C12orf39,NTS,CRH,HCRT,POMCA,CCK,AGRP,GRP,AVP,PNOC |
| protein binding | NHP2L1,ST8SIA5,RYR2,COLQ,NDUFB9,TMEM59,RASSF1,PA2G4,GNG12,UCHL3 |
| opioid peptide activity | ZFP106,PNOC,PDYN,CDC42EP2 |
Interacting Protein
PENK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PENK here. Most of them are supplied by our site. Hope this information will be useful for your research of PENK.
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References
- Subiran, N; Candenas, L; et al. Autocrine regulation of human sperm motility by the met-enkephalin opioid peptide. FERTILITY AND STERILITY 98:617-U382(2012).
- Hanrieder, J; Ljungdahl, A; et al. L-DOPA-induced Dyskinesia is Associated with Regional Increase of Striatal Dynorphin Peptides as Elucidated by Imaging Mass Spectrometry. MOLECULAR & CELLULAR PROTEOMICS 10:-(2011).
