PDE1A
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Official Full Name
PDE1A phosphodiesterase 1A, calmodulin-dependent -
Overview
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic;nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime;monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent;PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 (PubMed 11342109);;Fidock et al., 2002 (PubMed 11747989)). -
Synonyms
PDE1A;phosphodiesterase 1A, calmodulin-dependent;calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1A;hCam-1;cam-PDE 1A;61 kDa Cam-PDE;phosphodiesterase-1A;calmodulin-dependent phosphodiesterase;3,5 cyclic nucleotide phosphodiesterase;calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase;HCAM1;HSPDE1A;MGC26303
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- HEK293T
- Mammalian cells
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
PDE1A involved in several pathways and played different roles in them. We selected most pathways PDE1A participated on our site, such as Purine metabolism,Calcium signaling pathway,Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Olfactory transduction | OR4D6,OLFR186,OLFR958,PRKACA,OLFR478,OR11A1,OLFR15,OLFR24,OR2A4,OLFR498 |
| Taste transduction | PRKACG,TAS2R118,GNG3,TAS2R130,TAS1R1,TAS2R143,TAS2R20,ITPR3,TAS2R139,PRKACB |
| Renin secretion | PRKG2,PLCB4,ORAI1,ACE,PRKACA,CALM4,GNAI3,PRKACB,PPP3R1,LOC100328615 |
| Purine metabolism | ADCY1B,ADKA,NME3,POLD2,NT5C1B-RDH14,AK8,PAICS,XDH,GART,PDE7B |
| Calcium signaling pathway | CALM2,PHKG1B,ITPKA,CAMK2B1,CHRM5B,PLN,CACNA1C,CALM,TACR2,CALM2B |
Protein Function
PDE1A has several biochemical functions, for example, calmodulin binding,calmodulin-dependent cyclic-nucleotide phosphodiesterase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE1A itself. We selected most functions PDE1A had, and list some proteins which have the same functions with PDE1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin-dependent cyclic-nucleotide phosphodiesterase activity | PDE1B,PDE1C,TDP2B,USB1 |
| calmodulin binding | C2orf62,MYO1D,KCNN1A,SLC8A2,PATE4,AEBP1,MYO6,PPP3CA,CAMK2A,REM1 |
| metal ion binding | PMM1,MAP3K2,ARSK,NUDT11,GUCY1B3,ZFY1,MSRB1A,HPDB,GALNTL2,CA4B |
Interacting Protein
PDE1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE1A.
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References
- Matsumoto, C; Ito, M; et al. Genes that characterize T-3-predominant Graves' thyroid tissues. EUROPEAN JOURNAL OF ENDOCRINOLOGY 168:137-144(2013).
- Santone, R; Giorgi, M; et al. Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina. JOURNAL OF NEUROSCIENCE RESEARCH 84:1020-1026(2006).
