PDCD10
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Official Full Name
programmed cell death 10 -
Overview
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
PDCD10;programmed cell death 10;CCM3, cerebral cavernous malformations 3;programmed cell death protein 10;TFAR15;apoptosis-related protein 15;TF-1 cell apoptosis-related protein 15;cerebral cavernous malformations 3 protein;CCM3;MGC1212;MGC2447
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Human Cells
- HEK293T
- GST
- Non
- His
- T7
- His&Strep
- Myc&DDK
- His&Fc&Avi
- His&SUMO
Involved Pathway
PDCD10 involved in several pathways and played different roles in them. We selected most pathways PDCD10 participated on our site, such as Validated targets of C-MYC transcriptional activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDCD10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Validated targets of C-MYC transcriptional activation | DDX18,HUWE1,SERPINI1,MINA,LIN28B,NDUFAF2,MTDH,PRDX3,IREB2,PEG10 |
Protein Function
PDCD10 has several biochemical functions, for example, protein N-terminus binding,protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDCD10 itself. We selected most functions PDCD10 had, and list some proteins which have the same functions with PDCD10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | NEK6,RPTOR,PEBP1,CAV1,PTPN2,BCL2L1,CHEK2,EEF2,TRP53,FZD5 |
| protein homodimerization activity | KCNK9,SUPV3L1,NR6A1,ANO2,LHPP,ATPIF1,PDZD7,PDK2,NR4A2,BAK1 |
| protein binding | LSM2,FBLN1,NPC1,GAST,SMAD9,G6PD,BLOC1S2,ARSA,PABPC4,RQCD1 |
| protein N-terminus binding | STX1A,ATM,FEZ1,THAP7,GLRX,SUV39H1,NBN,RND2,TSC1,NIPBL |
Interacting Protein
PDCD10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDCD10 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDCD10.
STK25;STK24
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