PCDHB14
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Official Full Name
protocadherin beta 14 -
Overview
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3 exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. -
Synonyms
PCDHB14;protocadherin beta 14;protocadherin beta-14;PCDH BETA14;MGC120065;PCDHB 14;PCDH-beta-14;OTTHUMP00000160019;PCDH-BETA14
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PCDHB14-12448M | Recombinant Mouse PCDHB14 Protein | Mammalian Cells | Mouse | His |
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| Pcdhb14-1915M | Recombinant Mouse Pcdhb14 Protein, His-tagged | E.coli | Mouse | His | Thr30-Arg189 |
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| PCDHB14-6544M | Recombinant Mouse PCDHB14 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PCDHB14-6544M-B | Recombinant Mouse PCDHB14 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PCDHB14 involved in several pathways and played different roles in them. We selected most pathways PCDHB14 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCDHB14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PCDHB14 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCDHB14 itself. We selected most functions PCDHB14 had, and list some proteins which have the same functions with PCDHB14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CDHR1A,MYL2B,SYTL4,CDH4,NELL2,CCDC102A,PCDHB6,PCDH1A4,PNLIPRP1,LRP2A |
Interacting Protein
PCDHB14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCDHB14 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCDHB14.
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References
- van Helden, YGJ; Godschalk, RWL; et al. Organ specificity of beta-carotene induced lung gene-expression changes in Bcmo1(-/-) mice. MOLECULAR NUTRITION & FOOD RESEARCH 57:307-319(2013).
- O'Leary, R; Reilly, JE; et al. A variable cytoplasmic domain segment is necessary for gamma-protocadherin trafficking and tubulation in the endosome/lysosome pathway. MOLECULAR BIOLOGY OF THE CELL 22:4362-4372(2011).
