PCDHB12
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Official Full Name
protocadherin beta 12 -
Overview
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3 exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. -
Synonyms
PCDHB12;protocadherin beta 12;protocadherin beta-12;PCDH BETA12;PCDHB 12;PCDH-beta-12;OTTHUMP00000160020;PCDH-BETA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PCDHB12-1562H | Recombinant Human PCDHB12, His-tagged | E.coli | Human | His | 6-350aa | |
| PCDHB12-101H | Recombinant Human PCDHB12 protein, AFPn/His-tagged | E.coli | Human | His&AFPn | 27-690 a.a. |
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| PCDHB12-4295R | Recombinant Rat PCDHB12 Protein | Mammalian Cells | Rat | His |
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| PCDHB12-3957R | Recombinant Rat PCDHB12 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PCDHB12-3957R-B | Recombinant Rat PCDHB12 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
PCDHB12 involved in several pathways and played different roles in them. We selected most pathways PCDHB12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCDHB12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PCDHB12 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCDHB12 itself. We selected most functions PCDHB12 had, and list some proteins which have the same functions with PCDHB12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | ZFP652,SGCA,DSG1,RHOT2,PCDH1G18,PCDH2G29,CDHR1A,ITSN2B,MMP12,FKBP10B |
Interacting Protein
PCDHB12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCDHB12 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCDHB12.
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References
- Melka, MG; Castellani, CA; et al. Olanzapine-induced methylation alters cadherin gene families and associated pathways implicated in psychosis. BMC NEUROSCIENCE 15:-(2014).
- Lu, CC; Appler, JM; et al. Developmental Profiling of Spiral Ganglion Neurons Reveals Insights into Auditory Circuit Assembly. JOURNAL OF NEUROSCIENCE 31:10903-10918(2011).
