PAX2
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Official Full Name
paired box 2 -
Overview
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] -
Synonyms
PAX2;paired box 2;PAPRS;paired box protein Pax-2;paired box homeotic gene 2
Recombinant Proteins
- Mouse
- Human
- Chicken
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- GST
- Avi&Fc&His
- DDK&Myc
Involved Pathway
PAX2 involved in several pathways and played different roles in them. We selected most pathways PAX2 participated on our site, such as Id Signaling Pathway,Wnt Signaling Pathway NetPath, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt Signaling Pathway NetPath | ROR2,HIPK2,BCL9,MARK2,MAP1B,TFAP2A,SALL1,CSNK2A1P,CRYBB2,TCF4 |
| Id Signaling Pathway | ACVRL1,MSC,KDR,IFI16,TCF3B,ELK3,TCF12,MYF6,MYOG,MYOD1 |
Protein Function
PAX2 has several biochemical functions, for example, DNA binding,core promoter proximal region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX2 itself. We selected most functions PAX2 had, and list some proteins which have the same functions with PAX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | UBE2I,MED1,FIGLA,PPP1R13L,BPTF,TNFRSF10A,RNF19A,HEY2,PPP1R13BB,TWIST1 |
| superoxide-generating NADPH oxidase activity | NOX4,SH3PXD2AA,CYBB,NOX5,NOX3,NOX1,NCF1 |
| DNA binding | ZNF302,MIS18BP1,ZNF221,SP140,DMRT3A,NFE2L1B,ZNF518A,FOXE3,ZNF157,RFX1A |
| protein binding | FAM129A,PEX16,C1orf50,CCDC41,ISCA2,CAND1,THOC7,MTA2,CD1B,NOSIP |
| transcription regulatory region DNA binding | GLI1,ZNF831,KCNA3,FOXI1,BRD7,H2AFY,HHEX,REST,CEBPA,HIVEP3 |
| core promoter proximal region sequence-specific DNA binding | SMAD4,CXXC1,DMRT3,GATA3,SP3,DMRTA2,TFAP2A,KLF1,KLF4,DMRT2 |
Interacting Protein
PAX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX2.
BBS7;BBS1;BBS4;BBS2;GLCE;SNAI1;TRIM25;IL13RA2;BLID;KLK6;RASL10B;WHSC1L1;PRDM14;BEX1;VPS45;MRC2
Resources
Research Area
Renal MarkersEarly Ectodermal Lineage Markers
Epithelial Stem Cell Transcription Factors
Intracellular Signaling Molecules in Angiogenesis
Pluripotent Stem Cell Transcription Factors
Ectodermal Lineage Markers
Related Services
Related Products
References
- Stewart, CJR; Crook, ML; et al. PAX2 and Cyclin D1 Expression in the Distinction Between Cervical Microglandular Hyperplasia and Endometrial Microglandular-like Carcinoma: A Comparison With p16, Vimentin, and Ki67. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY 34:90-100(2015).
- Gutierrez-Mecinas, M; Watanabe, M; et al. Expression of gastrin-releasing peptide by excitatory interneurons in the mouse superficial dorsal horn. MOLECULAR PAIN 10:-(2014).
