PARP4
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Official Full Name
poly (ADP-ribose) polymerase family, member 4 -
Overview
This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. -
Synonyms
PARP4;poly (ADP-ribose) polymerase family, member 4;ADP ribosyltransferase (NAD+;poly (ADP ribose) polymerase) like 1 , ADPRTL1;poly [ADP-ribose] polymerase 4;p193;VAULT3;von Willebrand factor A domain containing 5C;VPARP;VWA5C;PARP-related;H5
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PARP4-156H | Recombinant Human PARP4 protein, GST-tagged | Wheat Germ | Human | GST | 31-140 a.a. |
|
| PARP4-2162H | Recombinant Human PARP4, His-tagged | E.coli | Human | His | 220-574 a.a. |
|
| PARP4-4049C | Recombinant Chicken PARP4 | Mammalian Cell | Chicken | His |
|
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| PARP4-8198H | Recombinant Human PARP4 protein, His & T7-tagged | E.coli | Human | His&T7 | Val338~Thr609 |
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| PARP4-1291H | Recombinant Human PARP4 protein(607-1046aa), His-tagged | E.coli | Human | His | 607-1046aa |
|
Involved Pathway
PARP4 involved in several pathways and played different roles in them. We selected most pathways PARP4 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | APEX2,MBD4,xthA,UNG,LIG1,POLD4,HMGB1,NEIL1,SMUG1,POLL |
Protein Function
PARP4 has several biochemical functions, for example, DNA binding,NAD+ ADP-ribosyltransferase activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARP4 itself. We selected most functions PARP4 had, and list some proteins which have the same functions with PARP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | BCHE,GOLPH3,CABYR,PRKCA,NCOA1,BRCA1,DYM,ABCD1,SLC27A2,GSTM4 |
| protein binding | CHRNA5,CCDC167,PIK3R6,TBC1D17,CCT3,PRMT1,PRKCZ,ADAMTSL3,THRAP3,CHRAC1 |
| NAD+ ADP-ribosyltransferase activity | PARP6,GIG2F,GIG2D,PARP16,GIG2O,CHAT1,CHAT2,ART3,PARP3,SIRT4 |
| DNA binding | FOXO6,DNASE1L1,ZNF19,TAF1L,ZNF223,PHC3,ZNF572,ZFP473,HOXC11A,ZNF669 |
Interacting Protein
PARP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARP4.
ORF;brrf1_ebvg;CCT6A;SMAD3;purL;flgE;trpE;q81m31_bacan;q81uh3_bacan;cof4;fimD7;flgH2;q9wmx2-pro_0000037548;2_aha_camp;CLTC;Lgals3bp;SNW1
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