PARD6A
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Official Full Name
par-6 family cell polarity regulator alpha -
Overview
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] -
Synonyms
PARD6A;par-6 family cell polarity regulator alpha;PAR6;PAR6C;TAX40;PAR-6A;TIP-40;PAR6alpha;partitioning defective 6 homolog alpha;PAR-6 alpha;Tax-interacting protein 40;tax interaction protein 40;partitioning-defective protein 6;partitioning defective-6 homolog alpha;par-6 partitioning defective 6 homolog alpha
Recombinant Proteins
- Rhesus macaque
- Rat
- Zebrafish
- Human
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PARD6A-3304R | Recombinant Rhesus monkey PARD6A Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| PARD6A-4271R | Recombinant Rat PARD6A Protein | Mammalian Cells | Rat | His |
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| PARD6A-5846Z | Recombinant Zebrafish PARD6A | Mammalian Cells | Zebrafish | His |
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| PARD6A-3436HCL | Recombinant Human PARD6A 293 Cell Lysate | HEK293 | Human | Non |
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| PARD6A-3122R | Recombinant Rhesus Macaque PARD6A Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PARD6A-3122R-B | Recombinant Rhesus Macaque PARD6A Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| PARD6A-3933R | Recombinant Rat PARD6A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PARD6A-3933R-B | Recombinant Rat PARD6A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
PARD6A involved in several pathways and played different roles in them. We selected most pathways PARD6A participated on our site, such as Rap signaling pathway,Endocytosis,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARD6A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | TCF7,YAP1,TEAD3,GDF7,ITGB2L,MPP5,LATS2,AREG,FZD8,CDH1 |
| Tight junction | CLDNA,F11R,F11R.1,MYH3,PRKCBA,CLDN11A,CLDN5A,PPP2CB,CLDN2,RHOA |
| Endocytosis | GRK7A,CAV3,CBLC,HSPA1A,VPS37C,IGF1RB,PSD4,RHOAC,HLA-G,FAM125B |
| Rap signaling pathway | FGF1,P2RY1,RAF1,FGF9,FGF13,CALML3,RAC2,ID1,VEGFC,PFN2 |
Protein Function
PARD6A has several biochemical functions, for example, GTP-dependent protein binding,Rho GTPase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARD6A itself. We selected most functions PARD6A had, and list some proteins which have the same functions with PARD6A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP-dependent protein binding | AP3B1,EEA1,RAB38,RASGRP4,RAB5B,CDC42,RAB32,AP1G1,HPS6,RAPGEF5 |
| transcription factor binding | PARK7,HDAC3,FLNA,GTF2F1,TNFRSF10A,RORA,PPP1R13BB,PIAS1,TFDP2,NKX2-1 |
| protein binding | TPT1,PKP4,Cd79a,CMKLR1,LINC01588,APOBEC2B,SFRP5,WRAP53,UBL7,ZBED3 |
| protein kinase C binding | PICK1,TOP2A,TRPV4,PKP2,SDPRB,ADD3,HDAC9,NELL2,DSP,HSPB1 |
| Rho GTPase binding | CDC42BPB,DAAM1B,DOCK10,DAPK3,IQGAP3,RHOH,ARHGEF16,PFN1,ROCK2A,AKAP13 |
Interacting Protein
PARD6A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARD6A here. Most of them are supplied by our site. Hope this information will be useful for your research of PARD6A.
PRKCI;PRKCZ
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References
- Lesiak, A; Pelz, C; et al. A Genome-Wide Screen of CREB Occupancy Identifies the RhoA Inhibitors Par6C and Rnd3 as Regulators of BDNF-Induced Synaptogenesis. PLOS ONE 8:-(2013).
- Jauregi-Miguel, A; Fernandez-Jimenez, N; et al. Alteration of Tight Junction Gene Expression in Celiac Disease. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 58:762-767(2014).
