PAPSS1
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Official Full Name
3-phosphoadenosine 5-phosphosulfate synthase 1 -
Overview
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 -
Synonyms
PAPSS1;3-phosphoadenosine 5-phosphosulfate synthase 1;bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;ATPSK1;PAPSS;SK 1;PAPSS 1;PAPS synthase 1;sulfurylase kinase 1;3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1;SK1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PAPSS1-1523H | Recombinant Human PAPSS1, GST-tagged | E.coli | Human | GST | 1-624aa | |
| PAPSS1-1390H | Recombinant Human 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1, His-tagged | E.coli | Human | His |
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| PAPSS1-6986Z | Recombinant Zebrafish PAPSS1 | Mammalian Cells | Zebrafish | His |
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| PAPSS1-471HCL | Recombinant Human PAPSS1 lysate | HEK293 | Human | Non |
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| PAPSS1-2102H | Recombinant Human PAPSS1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| PAPSS1-431H | Recombinant Human PAPSS1 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| Papss1-4674M | Recombinant Mouse Papss1 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| PAPSS1-5275H | Recombinant Human PAPSS1 Protein (Met1-Ala624), C-His tagged | Mammalian Cells | Human | His | Met1-Ala624 |
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Involved Pathway
PAPSS1 involved in several pathways and played different roles in them. We selected most pathways PAPSS1 participated on our site, such as Purine metabolism,Selenocompound metabolism,Sulfur metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAPSS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | PDE6A,NME7,ENTPD2A.1,GUCY2C,PNP5B,DCK,PRPS1A,HPRT1,AK3,PDE3B |
| Metabolic pathways | PCYT2,UGT2B15,PLCE1,ACOT8,ACSL4B,CKMT2,MTMR7,HSD11B1,PDXKB,FUK |
| Sulfur metabolism | MPST,BPNT1,PAPSS2A,CYCS,IMPAD1,PAPSS2,SUOX,CYCSB,PAPSS2B,ETHE1 |
| Selenocompound metabolism | SPS2,PSTK,TRR1,PAPSS2A,INMT,SEPSECS,MARS,MARS2,TXNRD1,PAPSS2B |
Protein Function
PAPSS1 has several biochemical functions, for example, ATP binding,adenylylsulfate kinase activity,nucleotidyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAPSS1 itself. We selected most functions PAPSS1 had, and list some proteins which have the same functions with PAPSS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotidyltransferase activity | CCDC111,CMASA,PRIM2,GMPPAA,TERT,GDPGP1,POLR3B,GMPPA,GMPPAB,OASL2 |
| adenylylsulfate kinase activity | PAPSS2,PAPSS2B,PAPSS2A |
| sulfate adenylyltransferase (ATP) activity | PAPSS2,PAPSS2A,PAPSS2B |
| ATP binding | KIF20B,SRR,EP400,PSKH2,ADCY1,FAM20B,LTK,INSRR,CDK10,ABCB3L1 |
Interacting Protein
PAPSS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAPSS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAPSS1.
Papss1;EEF1A1;UNC119;q81v12_bacan;PPP1R16A;RNASEH2A;NCK1;TMEM132A;Ppp2r1a;Tyw3;FANCI;Rhoa
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References
- Mueller, JW; Shafqat, N; et al. Adenosine-5-phosphosulfate - a multifaceted modulator of bifunctional 3-phospho-adenosine-5-phosphosulfate synthases and related enzymes. FEBS JOURNAL 280:3050-3057(2013).
- Leung, A; Kwok, B; et al. Silencing of PAPSS1 (3 '-phosphoadenosine 5 '-phosphosulfate synthase 1) potentiates cisplatin activity against non-small cell lung cancer.. CANCER RESEARCH 73:-(2013).
