PAH
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Official Full Name
Phenylalanine Hydroxylase -
Overview
Tyrosine hydrolase (TYH) is the enzyme which converts tyrosine to dihydroxyphenylalanine (L-dopa), a precursor of the catecholamine neurotransmitters dopamine, noradrenaline and adrenaline. Tryptophan hydrolase (TRH) is the enzyme that converts 5-hydroxytryptophan to serotonin. TRH can be used as a marker for serotonin as it converts 5-hydroxy-tryptophan to serotonin. Serotonin is rapidly metabolized and is unable to be detected by anti-serotonin antibodies in post mortem tissue. In human tissue that has been formalin-fixed, due to a change in the antigenic determinant of TYH, this product will bind only TRH. The antibody can therefore be used to specifically identify serotonergic neurons in fixed human tissues. Phenylalanine hydrolase (PAH) can be detected in hepatic tissue sections. -
Synonyms
PAH;Phe 4 monooxygenase;Phenylalanine hydrolase;Phenylalanine hydroxylase;PKU 1;PKU;PKU1
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Insect Cells
- Mammalian Cell
- HEK293T
- Wheat Germ
- Insect Cell
- HEK293
- Mammalian cells
- Human cells
- Yeast
- In Vitro Cell Free System
- His
- Myc&DDK
- His&SUMO
- Non
- GST
- His&Fc&Avi
- Flag
Involved Pathway
PAH involved in several pathways and played different roles in them. We selected most pathways PAH participated on our site, such as Phenylalanine metabolism,Phenylalanine, tyrosine and tryptophan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | UGT2B15,NAMPTB,CERS2,SEPHS1,DHCR7,MTHFR,GAL3ST1,NDUFS8B,HMGCRA,GKUP |
| Phenylalanine, tyrosine and tryptophan biosynthesis | GOT2B,GOT2A,GOT1,TAT,IL4I1,GOT2 |
| Biosynthesis of amino acids | TPI1A,PSAT1,PCXB,PKMA,RPE,ALDOAA,GOT2B,PRPS2,IDH3G,PKM2 |
| Phenylalanine metabolism | GM4952,MIF,MAOA,HPDA,GOT2,ALDH3B1,HPDB,GOT1,AOC2,MAOB |
Protein Function
PAH has several biochemical functions, for example, amino acid binding,cofactor binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAH itself. We selected most functions PAH had, and list some proteins which have the same functions with PAH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | CADM4,HNF1A,DMRTC1C2,MUC13,APOA2,RAB11FIP3,STK4,MTMR2,HINT2,CD200 |
| amino acid binding | GOT2,TH,AGXT,SHMT2,AARS,TPH1,ASS1,DDC,DPYS,TDO2 |
| cofactor binding | ACLY,TYMS,C3,LMO2,PHYH,BIRC5,HACL1,HIF1AN,DAO,ASNS |
| iron ion binding | CYP3A5,NOS2A,CYGB2,BA1,CYP4F2,CYP17A2,CYP3A43,CH25H,CYP20A1,HBD |
| phenylalanine 4-monooxygenase activity | PCBD1,PCBD2 |
Interacting Protein
PAH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAH here. Most of them are supplied by our site. Hope this information will be useful for your research of PAH.
RPS24;v-bcl-2;pgm
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References
- Meng, XY; Li, YS; et al. An enzyme-linked immunosorbent assay for detection of pyrene and related polycyclic aromatic hydrocarbons. ANALYTICAL BIOCHEMISTRY 473:1-6(2015).
- Volkov, AV; Kurmukov, IA; et al. Impact of bosentan therapy on stress-induced pulmonary hypertension in patients with systemic sclerosis. TERAPEVTICHESKII ARKHIV 87:49-56(2015).
