PAFAH2
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Official Full Name
platelet-activating factor acetylhydrolase 2, 40kDa -
Overview
This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. -
Synonyms
PAFAH2;platelet-activating factor acetylhydrolase 2, 40kDa;platelet activating factor acetylhydrolase 2 (40kD);platelet-activating factor acetylhydrolase 2, cytoplasmic;HSD PLA2;EC 3.1.1.47;HSDPLA2;Platelet activating factor acetylhydrolase 2;Serine dependent phospholipase A2;SD-PLA2;serine-dependent phospholipase A2;HSD-PLA2
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His&T7
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PAFAH2-2119H | Recombinant Human PAFAH2 protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Leu392 |
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| PAFAH2-4256R | Recombinant Rat PAFAH2 Protein | Mammalian Cells | Rat | His |
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| PAFAH2-3466HCL | Recombinant Human PAFAH2 293 Cell Lysate | HEK293 | Human | Non |
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| Pafah2-021M | Recombinant Mouse Pafah2 Protein, MYC/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| PAFAH2-039H | Recombinant Human PAFAH2 Protein, His-tagged | E.coli | Human | His | 2-392 |
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| PAFAH2-19H | Recombinant Human PAFAH2 Protein, His-tagged | E.coli | Human | His | 2-392 |
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| PAFAH2-3918R | Recombinant Rat PAFAH2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PAFAH2-3918R-B | Recombinant Rat PAFAH2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PAFAH2-4791H | Recombinant Human PAFAH2 Protein (Met1-Leu392), N-His tagged | E.coli | Human | His | Met1-Leu392 |
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Involved Pathway
PAFAH2 involved in several pathways and played different roles in them. We selected most pathways PAFAH2 participated on our site, such as Ether lipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAFAH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ether lipid metabolism | PLA2G4AA,PLA2G6,PLD1,PLA2G4D,PPAP2B,AGPS,UGT8A,EPT1,CEPT1B,PLA2G12B |
| Metabolic pathways | ATPV0E2,ARG1,PMM2,PTGS1,PGK2,CKMT1B,AK8,MAN1C1,IDH3B,GATB |
Protein Function
PAFAH2 has several biochemical functions, for example, 1-alkyl-2-acetylglycerophosphocholine esterase activity,phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAFAH2 itself. We selected most functions PAFAH2 had, and list some proteins which have the same functions with PAFAH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phospholipid binding | NR5A1,FABP1,AGAP1,CPS1,PLA2G2A,MTAP1B,AMPH,ABCG1,PLEKHA3,F3 |
| 1-alkyl-2-acetylglycerophosphocholine esterase activity | PAFAH1B3,ASPG,PLA2G7,PAFAH1B2 |
Interacting Protein
PAFAH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAFAH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAFAH2.
Resources
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References
- Yan, JX; Hitomi, T; et al. Genetic Study of Intracranial Aneurysms. STROKE 46:620-+(2015).
- Latchoumycandane, C; Marathe, GK; et al. Oxidatively Truncated Phospholipids Are Required Agents of Tumor Necrosis Factor alpha (TNF alpha)-induced Apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY 287:17693-17705(2012).
