PAFAH1B3
-
Official Full Name
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -
Overview
This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with mental retardation, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described. -
Synonyms
PAFAH1B3;platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa);platelet-activating factor acetylhydrolase IB subunit gamma;PAF AH1b alpha 1 subunit;PA1B3_HUMAN;PAF acetylhydrolase 29 kDa subunit;PAF AH 29 kDa subunit;PAF AH subunit gamma;PAF-AH 29 kDa subunit;PAF-AH subunit gamma;PAFAH subunit gamma;PAFAHG;Platelet activating factor acetylhydrolase IB subunit gamma;Platelet activating factor acetylhydrolase isoform Ib gamma subunit (29kD);Platelet activating factor acetylhydrolase isoform Ib gamma subunit 29kDa;Platelet activating factor acetylhydrolase isoform Ib gamma subunit;PAF-AH1b alpha 1 subunit;platelet-activating factor acetylhydrolase, isoform Ib, subunit 3 (29kDa
Recombinant Proteins
- Zebrafish
- Human
- Rhesus macaque
- Rat
- Mouse
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PAFAH1B3 involved in several pathways and played different roles in them. We selected most pathways PAFAH1B3 participated on our site, such as Ether lipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAFAH1B3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | QDPR,PCXB,ATP6V1C1B,PDXK,EXT1,Acsm2a,POLR1B,PIGL,MTHFD1,IVD |
| Ether lipid metabolism | PPAP2A,LPCAT1,PLA2G2F,PLA2G10,PLA2G4D,PPAP2B,CEPT1B,PLA2G2E,PLA2G5,PAFAH1B1B |
Protein Function
PAFAH1B3 has several biochemical functions, for example, 1-alkyl-2-acetylglycerophosphocholine esterase activity,identical protein binding,platelet-activating factor acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAFAH1B3 itself. We selected most functions PAFAH1B3 had, and list some proteins which have the same functions with PAFAH1B3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| platelet-activating factor acetyltransferase activity | PAFAH1B2 |
| identical protein binding | MUL1,LUC7L,NFKB1,CRYAA,IMPA1,PACSIN2,DYNLT1B,SERPINA1,SYNE1,SHARPIN |
| 1-alkyl-2-acetylglycerophosphocholine esterase activity | PAFAH2,PAFAH1B2,ASPG,PLA2G7 |
| protein binding | PCGF6,NCOA1,USP49,USP22,BTF3L4,CIT,RIPK3,CLDN7,PECAM1,NPLOC4 |
| protein heterodimerization activity | IL12A,HIST1H2BA,BCL2,ANO9A,ATF2,HIST1H2B7,HIST1H2AK,ZHX2,AOC3,BOKB |
Interacting Protein
PAFAH1B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAFAH1B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAFAH1B3.
Pafah1b1;VCAM1;LNX1;GDF9;GAPDH;TP53;XRCC6;GBP2;TERF1;SUMO2;EEF1A1;PAFAH1B2
Resources
Related Services
Related Products
References
- Warburton, A; Savage, AL; et al. Molecular signatures of mood stabilisers highlight the role of the transcription factor REST/NRSF. JOURNAL OF AFFECTIVE DISORDERS 172:63-73(2015).
- Mulvihill, MM; Benjamin, DI; et al. Metabolic Profiling Reveals PAFAH1B3 as a Critical Driver of Breast Cancer Pathogenicity. CHEMISTRY & BIOLOGY 21:831-840(2014).
