Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Basal cell carcinoma FZD3,TP53,FZD10,PTCH2,WNT3A,WNT6,Fzd4,AXIN1,WNT1,GLI3
    Cell cycle STIL,DHFR,SMAD4,GMNN,DCTN2,ANAPC11,YWHAQB,MAU2,NCAPD2,CCNE2
    Transcriptional misregulation in cancer PBX3,LYL1,PML,TP53,TGFBR2,PBX1,SIX1,TLX1,IL-8,PER2
    Herpes simplex infection SRSF3,Casp3,IL12BA,TRAF3,IRF9,CDK1,SRSF2A,SRSF4,TAF6,CASP3B
    Thyroid hormone signaling pathway ATP1A4,THRB,RHEB,SLC2A1,PLCG2,PIK3R1,MED1,WNT4,ATP1B1,KAT2A
    MicroRNAs in cancer HDAC1,IGF2BP1,SPRY2,SLC7A1,BAK1,IRS2,MDM4,KRAS,CDC25B,DICER1
    Colorectal cancer SMAD2,AKT2,MLH1,BIRC5,LEF1,CASP9,RAC1,MSH6,MAPK9,TCF7
    MAPK signaling pathway GADD45AB,FGF16,MAPK8IP2,HRASB,ELK1,PDGFAA,FGF6B,FGF12,FGF6A,RAF1
    Hepatitis C CLDN22,BAD,CLDN6,AKT1,IFNA5,CLDN1,IFIT1,IKBKG,TLR3,NR1H3

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding GLIS1,GATA6,ALX1,HOXD8,ZIK1,ATF5,GATA2B,SNAI1,ZBTB11,ACTN4
    histone acetyltransferase binding TAF7,CREB1,MYOCD,TRIM68,TAF7L,TP53,PCNA,SIRT2,MTF1,EID1
    protein self-association SLC9A3R1,BCL10,AGTR1A,L1CAM,CCL5,PROSAPIP1,CTSC,AGA,ABCD3,AXIN1
    RNA polymerase II transcription factor binding TAL1,ATF4,PITX2,TEAD3,GATA5,GFI1B,MKX,KDM1A,GATA2,ZFPM2
    histone deacetylase regulator activity TP53,MAPK8,NCOR1
    transcription regulatory region DNA binding ASH2L,ZNF649,THRA,SALL2,DDIT3,HDAC1,ETV5,SNCA,WNT1,CREB3L1
    transcription cofactor binding CHD6,FOXO3,KLF4
    protease binding DERL1,BCL10,ADAM8A,TNF,Casp3,RYR1,CSTA,Cstb,ADAMTS4,SELL
    enzyme binding ECM1,C2orf56,CDC20,BIRC5,DVL1,RPS3,LGALS9,IL6R,PLAUR,BCHE

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All Trp53 Products

    Required fields are marked with *

    My Review for All Trp53 Products

    Required fields are marked with *