Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK&Myc
  • Avi&Fc&His

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Herpes simplex infection NFKB1,TAF6L,JAK2B,TAF9B,H2-AA,IFNA10,CUL1,TAF10,PTPN11,TBPL1
    Melanoma FGF5,NRAS,FGF16,MAPK3,RAF1,KRAS,HGF,PIK3CB,FGF2,AKT2
    Thyroid cancer CCDC6,RXRA,PPARG,RXRB,HRAS,TCF7,LEF1,TP53,TPM3,RET
    Hepatitis B IFNA14,IFNA13,GRB2,BCL2,CCNA2,ELK1,PTEN,CCNE2,EGR3,NFATC4
    MicroRNAs in cancer MCL1,GLS,PDGFRA,PLCG1,DNMT3B,EP300,ERBB2,MMP9,NRAS,WNT3
    Prostate Cancer SMARCC2,CREB3L3,CCNE1,ATF4,AKT2,LEF1,MAPK1,SPINK1,NOXA1,CREB5
    Endometrial cancer KRAS,ARAF,PIK3R2,AKT1,AXIN2,ERBB2,SOS1,PTEN,MAP2K2,HRAS
    PIK-Akt signaling pathway FLT4,ITGB7,IFNA12,GH1,RHEB,ITGB8,FGF4,ITGA10,ANGPT1,LAMA3
    Non-small cell lung cancer RXRG,RXRB,MAP2K1,PIK3CD,PIK3CA,PLCG1,FHIT,AKT2,NRAS,MAPK1

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    MDM2/MDM4 family protein binding RFWD3,PPARA,PSME3,CDK5RAP3,CAV1,CDKN2A
    protein N-terminus binding ERCC5,TARBP2,UNC13A,STX5,PPP1CC,DCTN4,PHB2,MAP2K1,PARP1,SNCA
    chromatin binding MEF2C,TOP2A,APITD1,PAX3,APTX,SSBP1,NEUROG1,STAG2,CAPNS2,CBFA2T3
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding NKX2,NR1I2,ALX4,MAFGA,BARX2,NEUROD2,SOX17,OVOL2,MSX1,ALX1
    protein kinase binding GPRC5B,SPRY2,TEX14,PPME1,CEP68,PRDX3,AGTR1A,RAD9,CCNL1A,EEF1A2
    RNA polymerase II core promoter sequence-specific DNA binding GBX2,HEYL,PAX8,HNF4A,TFAP2B,IRF7,RUVBL2,FOS,SFPI1,TP53
    histone acetyltransferase binding NR4A3,EPAS1,TRIP4,TP53,PAX6,CEBPB,SP1,TAF7L,HIF1A,EGR1
    protein self-association DVL2,AXIN1,ZSWIM2,AGA,PTH1R,CTSB,TRIM32,DYRK1A,ADAM8,SVIP
    ATP binding CSNK1G2B,CKMT2,CAMK1G,ABCD2,NME1,ALDH18A1,SMARCAL1,MAP2K2,MCCC2,AK5

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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