P4HA2
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Official Full Name
prolyl 4-hydroxylase, alpha polypeptide II -
Overview
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
P4HA2;prolyl 4-hydroxylase, alpha polypeptide II;procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide II;prolyl 4-hydroxylase subunit alpha-2;4 PH alpha 2;C P4Halpha(II);collagen prolyl 4 hydroxylase alpha(II);2-oxoglutarate-4-dioxygenase subunit alpha-2;4-PH alpha-2;P4HA2_HUMAN;Procollagen-proline;Prolyl 4 hydroxylase alpha 2 subunit;Prolyl 4 hydroxylase subunit alpha 2 [Precursor];4-PH alpha 2;C-P4Halpha(II);collagen prolyl 4-hydroxylase alpha(II);procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2;procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His&T7
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| P4HA2-1178H | Recombinant Human P4HA2 protein, His & T7-tagged | E.coli | Human | His&T7 | Ser207~Glu520 |
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| P4HA2-1307C | Recombinant Chicken P4HA2 | Mammalian Cell | Chicken | His |
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| P4HA2-1680Z | Recombinant Zebrafish P4HA2 | Mammalian Cell | Zebrafish | His |
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| P4HA2-3274R | Recombinant Rhesus monkey P4HA2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| P4HA2-3481HCL | Recombinant Human P4HA2 293 Cell Lysate | HEK293 | Human | Non |
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| P4HA2-1578H | Recombinant Human P4HA2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| P4HA2-3092R | Recombinant Rhesus Macaque P4HA2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| P4HA2-3092R-B | Recombinant Rhesus Macaque P4HA2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| P4ha2-4641M | Recombinant Mouse P4ha2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| P4HA2-5266H | Recombinant Human P4HA2 Protein (Ser207-Glu520), N-His tagged | E.coli | Human | His | Ser207-Glu520 |
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Involved Pathway
P4HA2 involved in several pathways and played different roles in them. We selected most pathways P4HA2 participated on our site, such as Arginine and proline metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ALP3,ASPA,LIPT1,ABO,POLD4,PPT1,CHSY3,PCK1,SDSL,COMTB |
| Arginine and proline metabolism | MAOB,SAT1A.2,OAT,CKMT1A,PYCR1A,PYCR2,CKMT1B,ABP1,PYCRL,ALDH3A2 |
Protein Function
P4HA2 has several biochemical functions, for example, L-ascorbic acid binding,electron carrier activity,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HA2 itself. We selected most functions P4HA2 had, and list some proteins which have the same functions with P4HA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | UBE2D2A,HPS1,BEGAIN,KEAP1,VDR,GABARAP,GGA1,PLCG1,UFC1,IKBKE |
| electron carrier activity | IVD,NDUFV2,CIAPIN1,COX5A,NDUFS6,AOX3,ETFDH,UQCR11,ACOX3,CYP19A1 |
| L-ascorbic acid binding | P4HTM,P4HA1,EGLN1B,PHYH,PLOD1,LEPREL2,OGFOD2,EGLN1,TMLHE,PAM |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | ADOA,ALOX8,ALOX5A,P4HA1,BCO2,P4HA3,ALOX5B.3,P4HA1B,ALOX12E,ALOX12B |
| iron ion binding | CYP2D6,CYP4F18,ALOX12,CYP2F1,CYP51A1,CYP1A,LEPREL1,CYP4V2,ISCUB,TMLHE |
| procollagen-proline 4-dioxygenase activity | P4HA1,P4HA3,P4HA1A,P4HA1B |
Interacting Protein
P4HA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HA2.
DMWD;CREB3;PRRC2A;IRS4;cona_canen;env;H2AFX;EBNA-LP
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