P2RY12
-
Official Full Name
purinergic receptor P2Y, G-protein coupled, 12 -
Overview
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene. -
Synonyms
P2RY12;purinergic receptor P2Y, G-protein coupled, 12;P2Y purinoceptor 12;HORK3;P2Y12;SP1999;ADP-glucose receptor;purinergic receptor P2RY12;P2Y12 platelet ADP receptor;Gi-coupled ADP receptor HORK3;G-protein coupled receptor SP1999;putative G-
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Cynomolgus
- Mouse
- Macaca fascicularis
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- In vitro E. coli expression system
- HEK293T
- Mammalian cells
- E.coli expression system
- GST
- His
- Non
- His&Flag
- His&Fc&Avi
- Myc&DDK
- Flag
- Fc
Involved Pathway
P2RY12 involved in several pathways and played different roles in them. We selected most pathways P2RY12 participated on our site, such as Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RY12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Platelet activation | PLCB2,BTK,PRKG2,PIK3R1,PIK3CG,F2RL3,PIK3R5,MAPK11,SNAP23,MYL12A |
Protein Function
P2RY12 has several biochemical functions, for example, ADP receptor activity,G-protein coupled adenosine receptor activity,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RY12 itself. We selected most functions P2RY12 had, and list some proteins which have the same functions with P2RY12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled adenosine receptor activity | ADORA2A,ADORA1,ADORA2AB,ADORA2AA,ADORA2B,ADORA3 |
| guanyl-nucleotide exchange factor activity | ARFGEF2,ANKRD27,TRIOA,FGD2,DOCK11,TBC1D10A,KALRN,GCGR,FGD1,RABIF |
Interacting Protein
P2RY12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RY12 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RY12.
Resources
Related Services
Related Products
References
