P2RX2

  • Official Full Name

    purinergic receptor P2X, ligand-gated ion channel, 2

  • Overview

    The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]

  • Synonyms

    P2RX2;purinergic receptor P2X, ligand-gated ion channel, 2;P2X2;DFNA41;P2X purinoceptor 2;ATP receptor;P2X Receptor, subunit 2

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • Mouse
  • HEK293
  • Mammalian Cells
  • DDK
  • Myc
  • His
  • Non
  • Avi
  • Fc

    Involved Pathway

    P2RX2 involved in several pathways and played different roles in them. We selected most pathways P2RX2 participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway EDNRBA,PLN,PRKACAA,HTR2A,GRIN1B,HTR7,PRKACA,TNNC2,CCKAR,ATP2A3
    Neuroactive ligand-receptor interaction F2R,PTGER4C,LOC780933,GABRR3,C5AR1,GPR156,CCKAR,F2RL1.1,NPFFR2.1,TAAR5

    Protein Function

    P2RX2 has several biochemical functions, for example, ATP binding,cadmium ion binding,cobalt ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX2 itself. We selected most functions P2RX2 had, and list some proteins which have the same functions with P2RX2. You can find most of the proteins on our site.

    Function Related Protein
    mercury ion binding PARK7
    phosphatidylinositol binding TULP3,ING2,SNX16,SGK3,PIK3C2B,WDR35,SNX19A,SNX12,TULP4,RAG2
    zinc ion binding XIRP2,TNFAIP3,MYLIPA,BIRC2,RXRBB,MORC2B,Car2,UNK,ZFP330,TRAF2
    purinergic nucleotide receptor activity P2RX3A,P2RX3,P2RX4,P2RX4A,P2RX4B,P2RX5,P2RX8,NNR,P2RX3B,P2RX7
    ligand-gated ion channel activity ZACN,GABRB1,ANXA6,CLCA5,Chrng,CNGA3,CHRNA4,TRPA1A,CHRNB1,CHRNA3
    cobalt ion binding SLC11A2,BIRC5,PML,NUDT16
    extracellular ATP-gated cation channel activity P2RX3B,P2RX1,P2RX5,P2RX3,P2RX4,NNR,P2RX4A,P2RX6,P2RX8,P2RX3A
    identical protein binding KLHL7,RUNX1T1,SCUBE1,MSANTD3,DYNLT1B,HJURP,INHBA,SERPINA1E,TRP53,PARK2
    copper ion binding HEPH,SCO2,SNAI3,AOC3,F5,P2RX4,TYRP1B,HEPHL1A,COX11,LOXL3A

    Interacting Protein

    P2RX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX2.

    Resources

    Research Area

    Ion Channels and Regulators

    References

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