OSMR
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Official Full Name
oncostatin M receptor -
Overview
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
OSMR;oncostatin M receptor;oncostatin-M-specific receptor subunit beta;OSMRB;MGC140467;MGC150626;MGC150627;MGC75127;Oncostatin M specific receptor subunit beta;Oncostatin M-specific receptor, beta;IL-31RB;IL-31R-beta;IL-31R subunit beta;IL-31 receptor subunit beta;interleukin-31 receptor subunit beta;oncostatin-M specific receptor beta subunit;PLCA1
Recombinant Proteins
- Human
- Mouse
- Rat
- Cynomolgus
- HEK293
- Mammalian cells
- E.coli
- Mammalian Cell
- Human Cell
- Rabbit
- C-His
- His
- Fc
- Non
- His&T7
- His&GST
- His&Fc&Avi
- Myc&DDK
- His&Myc
Involved Pathway
OSMR involved in several pathways and played different roles in them. We selected most pathways OSMR participated on our site, such as Cytokine-cytokine receptor interaction,PIK-Akt signaling pathway,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with OSMR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | PIAS4A,CISH,IFNAR2,HRAS,Ifna15,IL22RA2,LEPB,PIAS1,STAT5B,PIAS4B |
| PIK-Akt signaling pathway | EIF4E1B,MLST8,IFNA13,TCL1B1,PPP2R3C,YWHAB,IFNA4,COL6A5,RELA,CREB5 |
| Cytokine-cytokine receptor interaction | IL3RA,IFNA6,CLCF1,CXCL13,MPL,CCL1,CRFB2,CCR6A,CXCL10,IL6R |
Protein Function
OSMR has several biochemical functions, for example, growth factor binding,contributes_to oncostatin-M receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OSMR itself. We selected most functions OSMR had, and list some proteins which have the same functions with OSMR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to oncostatin-M receptor activity | LIFR,IL6ST |
| growth factor binding | LTBP4,RPL37,KDR,TEK,RHBDF1,IGFBP2A,REG3B,RHBDF2,SDCBP,NRP1 |
Interacting Protein
OSMR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OSMR here. Most of them are supplied by our site. Hope this information will be useful for your research of OSMR.
ERBB2;GAPDH;q5nfj2_fratt;BAG3;Bmpr1a
Resources
Research Area
Negative Regulators of the Jak/STAT PathwayReceptors in the Jak/STAT Pathway
IL-6 Family Receptors
Related Services
Related Products
References
- Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
- Larrea, E; Echeverria, I; et al. Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection. JOURNAL OF HEPATOLOGY 60:482-489(2014).
