OS9
-
Official Full Name
osteosarcoma amplified 9, endoplasmic reticulum lectin -
Overview
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] -
Synonyms
OS9;osteosarcoma amplified 9, endoplasmic reticulum lectin;OS-9;ERLEC2;protein OS-9;erlectin 2;amplified in osteosarcoma 9;endoplasmic reticulum lectin 2;osteosarcoma amplified 9, endoplasmic reticulum associated protein
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
OS9 involved in several pathways and played different roles in them. We selected most pathways OS9 participated on our site, such as Asparagine N-linked glycosylation,Calnexin/calreticulin cycle,Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with OS9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hh mutants that dont undergo autocatalytic processing are degraded by ERAD | DERL2 |
| Hedgehog ligand biogenesis | GPC5A,DISP2,NOTUM1A,NOTUM,DERL2,HHAT,SCUBE2 |
| Hh mutants abrogate ligand secretion | DERL2 |
| Disease | TH1L,EPM2A,GPC6,RNF43,TTR,OPN1MW2,RDBP,AMN,LTF,CCDC59 |
| ER Quality Control Compartment (ERQC) | MAN1B1,DERL2 |
| Diseases of signal transduction | CPSF6,RBP4,RNF43,OPN1MW2,OPN1LW,JAG1,KREMEN2,CTBP1,FGFR1OP,HDAC5 |
| Asparagine N-linked glycosylation | PPP6C,TRAPPC3,TRAPPC6A,DAD1,TRAPPC1,TMED2,STT3A,NAPAB,CNIH3,GOLGA2 |
| Calnexin/calreticulin cycle | MAN1B1,DERL2 |
Protein Function
OS9 has several biochemical functions, for example, carbohydrate binding,glycoprotein binding,protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OS9 itself. We selected most functions OS9 had, and list some proteins which have the same functions with OS9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CCBE1,EVLA,SYNE1,CEACAM21,Apba1,PPHLN1,HADHB,MS4A1,ILKAP,NDUFA9 |
| glycoprotein binding | DNAJC5,SERPINA1A,CSNK1D,LGALS1,CANX,FBXO27,Serpina1c,SERPINA1E,FYN,FBXO2 |
| carbohydrate binding | CLEC5A,SIGLEC12,GALM,LGALS3,SFTPD,KRT1,GALNT11,ACAN,MAN2A1,LGALS2B |
| protease binding | DPP4,COMP,FLOT2,CRADD,TIMP2A,FURIN,SRI,ITGB3,HSPD1,NDUFS7 |
Interacting Protein
OS9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OS9 here. Most of them are supplied by our site. Hope this information will be useful for your research of OS9.
HIF1A;EGLN1;env;CREB3;EGLN3;DYSF;ACVR1B;SNRPD2
Resources
Related Services
Related Products
References
