ORC6L
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Official Full Name
ORC6 origin recognition complex, subunit 6 -
Overview
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. -
Synonyms
ORC6L;origin recognition complex subunit 6;OTTHUMP00000163361
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ORC6L-3246R | Recombinant Rhesus monkey ORC6L Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| ORC6L-3550HCL | Recombinant Human ORC6L 293 Cell Lysate | HEK293 | Human | Non |
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| ORC6L-3064R | Recombinant Rhesus Macaque ORC6L Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ORC6L-3064R-B | Recombinant Rhesus Macaque ORC6L Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
ORC6L involved in several pathways and played different roles in them. We selected most pathways ORC6L participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ORC6L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | KIF2A,GINS3,CDKN1C,GADD45AA,ZBTB17,SETB,GSK3B,CDC16,YWHAQA,CCNA1 |
Protein Function
ORC6L has several biochemical functions, for example, DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ORC6L itself. We selected most functions ORC6L had, and list some proteins which have the same functions with ORC6L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | AEBP1,RBM5,ATRX,ZNF280C,TADA2B,LMX1BA,DLX4B,ZNF292A,ISL2B,MEIS4.1A |
| protein binding | CSNK1G2,KCND3,NFE2L1,TRPC5,STX11,DTNBP1,SCP2,GRM2,PRH2,KIAA0947 |
Interacting Protein
ORC6L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ORC6L here. Most of them are supplied by our site. Hope this information will be useful for your research of ORC6L.
ORC3;LHX4;SPAG5;CDC7;ORC4;MCM4;MCM7;MCM2;MCM6;CDC6
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References
- Liao, H; Liu, XZJ; et al. Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924. MOLECULAR & CELLULAR PROTEOMICS 10:-(2011).
- Murai, S; Stein, P; et al. Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is essential for DNA replication in 1-cell embryos. DEVELOPMENTAL BIOLOGY 341:205-212(2010).
