ORC4L
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Official Full Name
ORC4 origin recognition complex, subunit 4 -
Overview
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. -
Synonyms
ORC4L;ORC4P;FLJ46668;origin recognition complex subunit 4;OTTHUMP00000162673;origin recognition complex, subunit 4-like;origin recognition complex, subunit 4 homolog
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ORC4L-3551HCL | Recombinant Human ORC4L 293 Cell Lysate | HEK293 | Human | Non |
|
Involved Pathway
ORC4L involved in several pathways and played different roles in them. We selected most pathways ORC4L participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ORC4L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | CENPI,STAG1,GORASP2,ANAPC2,PDS5B,RAD9A,NUPL2,LMNB1,CEP70,YWHAE1 |
Protein Function
ORC4L has several biochemical functions, for example, ATP binding,DNA replication origin binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ORC4L itself. We selected most functions ORC4L had, and list some proteins which have the same functions with ORC4L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SYN2A,DQX1,ABCB8,CDK5,ABCB10,MYO10,DTYMK,DCLK1,LYN,PRKCBA |
| protein binding | SRM,TXNRD2,SESN2,MID2,NUDT2,EIF5,KIAA1109,CDKN3,TEN1,PPP2R2B |
| nucleotide binding | GM711,U2AF2,EIF4BB,NXF3,BLM,MAPKAPK2B,HRASA,ABCG4B,CPEB2,HNRNPH1L |
| DNA replication origin binding | CDC45,MCM10,ORC4,HSPD1,MCM5,MCM2,ORC3L,ORC2L |
Interacting Protein
ORC4L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ORC4L here. Most of them are supplied by our site. Hope this information will be useful for your research of ORC4L.
ORC2;ORC1;RRM2B;ORC5;ORC3
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References
- Chung, BHY; Mullegama, S; et al. Severe intellectual disability and autistic features associated with microduplication 2q23.1. EUROPEAN JOURNAL OF HUMAN GENETICS 20:398-403(2012).
- Orange, JS; Glessner, JT; et al. Genome-wide association identifies diverse causes of common variable immunodeficiency. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 127:1360-U79(2011).
