ORC4
-
Official Full Name
origin recognition complex, subunit 4 -
Overview
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. -
Synonyms
ORC4L;ORC4P;FLJ46668;origin recognition complex subunit 4;OTTHUMP00000162673;origin recognition complex, subunit 4-like;origin recognition complex, subunit 4 homolog;ORC4;origin recognition complex, subunit 4
Recombinant Proteins
- Zebrafish
- Human
- Cynomolgus
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- His
- Non
- Myc&DDK
- His&Fc&Avi
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ORC4-12395Z | Recombinant Zebrafish ORC4 | Mammalian Cells | Zebrafish | His |
|
|
| ORC4-30514TH | Recombinant Human ORC4 | Wheat Germ | Human | Non | 248 amino acids |
|
| ORC4-769C | Recombinant Cynomolgus ORC4 Protein, His-tagged | Mammalian Cells | Cynomolgus | His |
|
|
| ORC4-1558H | Recombinant Human ORC4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
|
|
| ORC4-2850H | Recombinant Human ORC4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
|
|
| ORC4-288H | Recombinant Human ORC4 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| Orc4-4600M | Recombinant Mouse Orc4 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
|
|
| ORC4-513C | Recombinant Cynomolgus Monkey ORC4 Protein, His (Fc)-Avi-tagged | HEK293 | Cynomolgus | His&Fc&Avi |
|
|
| ORC4-513C-B | Recombinant Cynomolgus Monkey ORC4 Protein Pre-coupled Magnetic Beads | HEK293 | Cynomolgus |
|
||
| ORC4-703H | Recombinant Human ORC4 Protein (1-436 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1-436 aa |
|
Involved Pathway
ORC4 involved in several pathways and played different roles in them. We selected most pathways ORC4 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ORC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | CCNE2,GINS1,CDK2,CDK11B,RAD1,B9D2,STIL,SMAD4,NUP50,NUP35 |
Protein Function
ORC4 has several biochemical functions, for example, ATP binding,DNA binding,DNA replication origin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ORC4 itself. We selected most functions ORC4 had, and list some proteins which have the same functions with ORC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA replication origin binding | ORC2L,MCM5,ORC4L,MCM2,CDC45,HSPD1,ORC3L,MCM10 |
| nucleotide binding | MTIF2,ACTB1,CPEB4,GSPT1L,GNA15.4,RBM38,ARL8,U2AF1,TUBA1L,PRKCHB |
| DNA binding | NRL,ZFP90,TGIF2,DMBX1,ZNF483,SOX21,MYCB,ZNF710,NR6A1A,PCXB |
| ATP binding | RAD50,ERBB2,KTI12,DCLK2,NLRP11,CAMKK1B,PDGFRB,MSH4,MYH11,P2RX5 |
Interacting Protein
ORC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ORC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ORC4.
Resources
Related Services
Related Products
References
