ORC3
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Official Full Name
origin recognition complex, subunit 3 -
Overview
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. -
Synonyms
LAT;ORC3L;LATHEO;origin recognition complex subunit 3;OTTHUMP00000016835;OTTHUMP00000183452;homolog of latheo, Drosophila;origin recognition complex subunit Latheo;origin recognition complex, subunit 3-like;origin recognition complex, subunit 3 honolog;ORC3;origin recognition complex, subunit 3
Recombinant Proteins
- Zebrafish
- Mouse
- Chicken
- Rat
- Mammalian Cells
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ORC3-11999Z | Recombinant Zebrafish ORC3 | Mammalian Cells | Zebrafish | His |
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| ORC3-12185M | Recombinant Mouse ORC3 Protein | Mammalian Cells | Mouse | His |
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| ORC3-2758C | Recombinant Chicken ORC3 | Mammalian Cells | Chicken | His |
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| ORC3-4201R | Recombinant Rat ORC3 Protein | Mammalian Cells | Rat | His |
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| ORC3-3863R | Recombinant Rat ORC3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ORC3-3863R-B | Recombinant Rat ORC3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ORC3-6405M | Recombinant Mouse ORC3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ORC3-6405M-B | Recombinant Mouse ORC3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ORC3 involved in several pathways and played different roles in them. We selected most pathways ORC3 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ORC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | CENPJ,TUBGCP3,DCTN3,CSNK1E,H3F3D,ENSAB,SMC4,PRKDC,GADD45A,ANAPC11 |
Protein Function
ORC3 has several biochemical functions, for example, DNA binding,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by ORC3 itself. We selected most functions ORC3 had, and list some proteins which have the same functions with ORC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | Ar,HIST1H111R,ZFP668,ATM,ZNF582,ZFP64,HLTF,HIST1H101,MYNN,H1FNT |
| molecular_function | CEP78,CCDC113,MXRA8A,IFIT3,NOMO1,TP53I11B,C19orf57,DCUN1D4,CRYGM5,SMIM8 |
Interacting Protein
ORC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ORC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ORC3.
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