ORAI1
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Official Full Name
ORAI calcium release-activated calcium modulator 1 -
Overview
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). -
Synonyms
ORAI1;ORAI calcium release-activated calcium modulator 1;TMEM142A, transmembrane protein 142A;calcium release-activated calcium channel protein 1;calcium release activated calcium modulator 1;CRACM1;FLJ14466;protein orai-1;transmembrane protein 1
Recombinant Proteins
- Human
- Chicken
- Rat
- Xenopus laevis
- Mus musculus
- zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- GST
- Avi
- Fc
Involved Pathway
ORAI1 involved in several pathways and played different roles in them. We selected most pathways ORAI1 participated on our site, such as Calcium signaling pathway,cAMP signaling pathway,Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ORAI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aldosterone synthesis and secretion | CAMK1,CAMK2A,NR4A1,CYP11B2,ADCY1,PRKCE,CREB3L4,CALM3,CALM1,ATF2 |
| Primary i | CD3E,IL2RG,TAP2,BLNK,RFXAP,PTPRC,BTK,CD8A,CD8B,DCLRE1C |
| Platelet activation | RAP1A,GNAI3,TBXAS1,P2RX1,MAPK1,MYLK4,PRKACG,ARHGEF1,VAMP8,PLA2G4F |
| Calcium signaling pathway | DRD1B,P2RX5,P2RX4B,TRHR,CYSLTR2,PTK2BB,NOS2B,HTR6,PDE1A,HTR2B |
| nodeficiency | CD8B1,CD19,BLNK,RFXAP,DCLRE1C,TNFRSF13B,CD3D,RAG1,ZAP70,RFX5 |
| cAMP signaling pathway | SUCNR1,PPP1R12A,CAMK4,ATP1A1,HCAR2,HHIP,GABBR1,ATP2B4,BRAF,HTR4 |
| Renin secretion | GNAS,CLCA1,PLCB1,PLCB2,GNAI1,NPR1,GUCY1B3,GNAQ,GUCY1A3,PDE1C |
Protein Function
ORAI1 has several biochemical functions, for example, calmodulin binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ORAI1 itself. We selected most functions ORAI1 had, and list some proteins which have the same functions with ORAI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | C1QTNF9,HSP90AA1,POLG2,DAAM1,MTSS1,CLDN9,ALDOA,EID3,FRS3,LRRK1 |
| protein binding | DNAJC27,GSN,ADAP1,DDX21,UQCC1,RXFP1,FANCM,CD300A,HDDC2,FAM189B |
| calmodulin binding | MKNK2,ENKUR,EEA1,MYO3A,TJP1,TRPC2,CAMK1G,MYH4,MAP6,MARCKSL1 |
| store-operated calcium channel activity | TRPC4,ORAI3,TRPC7A,TRPC6A,TRPC7,ORAI1B,TRPC5A,TRPC1,TRPC5,TRPC6 |
Interacting Protein
ORAI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ORAI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ORAI1.
STIM1;ATP2C2
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References
- Gaida, K; Salimi-Moosavi, H; et al. Inhibition of CRAC with a human anti-ORAI1 monoclonal antibody inhibits T-cell-derived cytokine production but fails to inhibit a T-cell-dependent antibody response in the cynomolgus monkey. JOURNAL OF IMMUNOTOXICOLOGY 12:164-173(2015).
- Guzman, R; Valente, EG; et al. Expression of ORAI1, a Plasma Membrane Resident Subunit of the CRAC Channel, in Rodent and Non-rodent Species. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 62:864-878(2014).
