OPRD1
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Official Full Name
opioid receptor, delta 1 -
Overview
The opioid receptors are G-protein coupled, seven-transmembrane domain receptors for enkephalins, endorphins, and dynorphins. Three different opioid receptor subtypes (kappa, delta, and mu) were first identified by their different selectivities for various naturally occurring alkaloid opioid ligands, and subsequently confirmed by molecular cloning. The amino acid sequences of the opioid receptor subtypes are ~70% homologous, and are similar to somatostatin receptors (SSTRs) showing ~40 % homology with SSTR1. -
Synonyms
Delta type opioid receptor;Delta type opioid receptor DOR 1;DOR 1;DOR1;mDOR;Nbor;Opioid receptor delta 1;OPRD;OPRD1;delta-type opioid receptor;DOR-1;D-OR-1;OTTHUMP00000003778;delta opioid receptor 1;Opioid Receptor, delta
Recombinant Proteins
- Rat
- Human
- Mus musculus
- Sus scrofa (Pig)
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- Flag
- Avi
- Fc
Involved Pathway
OPRD1 involved in several pathways and played different roles in them. We selected most pathways OPRD1 participated on our site, such as cGMP-PKG signaling pathway,Sphingolipid signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with OPRD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | CCKAR,HTR1B,HTR6,PARD3,DRD4-RS,MC4R,TAAR9,GRM3,Chrng,GLRA2 |
| cGMP-PKG signaling pathway | PLCB4,GNAI3,GNA12,PPP1CA,GTF2I,CALM3,INS,MEF2C,ATP2B1,MEF2D |
| Sphingolipid signaling pathway | S1PR2,RAC2,PIK3R5,MAPK9,PPP2R2A,S1PR5,PIK3R2,PRKCB,PLCB2,PLCB1 |
Protein Function
OPRD1 has several biochemical functions, for example, enkephalin receptor activity,neuropeptide binding,opioid receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OPRD1 itself. We selected most functions OPRD1 had, and list some proteins which have the same functions with OPRD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| neuropeptide binding | MRGPRB1,MC3R,ADCYAP1R1,OPRK1,NPBWR2,SSTR1,SSTR4,GALR1,MRGPRX2,SSTR5 |
| enkephalin receptor activity | OPRD1B,OPRD1A |
| protein binding | NCAM1A,FAM206A,RPS27,PRDM13,PFDN4,SPRYD7,RSPH1,TEX264,POR,C21orf119 |
| opioid receptor activity | OPRD1A,SIGMAR1,OPRK1,NPBWR2,OGFR,NPBWR1,OPRD1B |
Interacting Protein
OPRD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OPRD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of OPRD1.
ATP2A2;GPRASP1;ATP2A2;CANX;dpdpe
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References
- Saxon, AJ; et al. Commentary on Burns et al. (2015): Retention in buprenorphine treatment. ADDICTION 110:656-657(2015).
- Vakonaki, E; Tzatzarakis, M; et al. A commonly intronic variant in OPRD1 is associated with buprenorphine response in former heroin users. TOXICOLOGY LETTERS 229:S95-S95(2014).
