Ogt
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Official Full Name
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
Recombinant Proteins
- Human
- Bacillus subtilis
- Mouse
- Rat
- E.coli
- E.Coli/Yeast
- Mammalian Cells
- Insect Cells
- HEK293
- GST
- His
- Flag
- Non
- Avi
- Fc
- DDK
- Myc
- SUMO
Involved Pathway
Ogt involved in several pathways and played different roles in them. We selected most pathways Ogt participated on our site, such as Other types of O-glycan biosynthesis,Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ogt were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | IRS1,PPARA,PTPN11A,PTPRF,PPP1R3C,NR1H3,INS2,RPS6KB1,SLC2A1A,PPP1R3A |
| Other types of O-glycan biosynthesis | B4GALT1,B3GAT2,FUT9A,B3GAT1,GXYLT1B,B3GALTLA,PLOD3,POFUT1,ST3GAL3B,C3orf64 |
Protein Function
Ogt has several biochemical functions, for example, acetylglucosaminyltransferase activity,enzyme activator activity,contributes_to histone acetyltransferase activity (H4-K16 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by Ogt itself. We selected most functions Ogt had, and list some proteins which have the same functions with Ogt. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein N-acetylglucosaminyltransferase activity | EOGT,B3GNT8,OGT.1,C3orf64 |
| phosphatidylinositol-3,4,5-trisphosphate binding | D6WSU116E,JPH2,RS1,PHLDA3,ASAP1,COMMD1,PIRT,RACGAP1,ARHGAP9,ZFYVE1 |
| enzyme activator activity | SAE1,ALOX5AP,RAB3GAP2,MMP24,HSPB2,DBNL,TAB1,CTSA,CTAGE5,GM1679 |
| contributes_to histone acetyltransferase activity (H4-K8 specific) | HCFC1,KANSL2,KANSL3,KIAA1267,MCRS1,KAT8,PHF20B |
| contributes_to histone acetyltransferase activity (H4-K16 specific) | MCRS1,KANSL2,KANSL3,PHF20B,HCFC1,KAT8,KIAA1267 |
| acetylglucosaminyltransferase activity | GALNTL4,4931440L10Rik,POMGNT2,UGGT1,XYLT1,C3orf39,B3GNT9-PS,DPY19L1,MGAT1,HEXA |
| contributes_to histone acetyltransferase activity (H4-K5 specific) | KANSL3,PHF20B,MCRS1,KANSL2,KAT8,KIAA1267,HCFC1 |
| protein O-GlcNAc transferase activity | GTDC2,C3orf39 |
| protein binding | ARHGEF15,ELF3,SCMH1,DHH,MYOCD,BECN1,CFL2,HOMER2,PEX1,EVI5 |
Interacting Protein
Ogt has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ogt here. Most of them are supplied by our site. Hope this information will be useful for your research of Ogt.
HCFC1;NUP62CL;TET2
Resources
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References
- Bauer, C; Gobel, K; et al. Phosphorylation of TET Proteins Is Regulated via O-GlcNAcylation by the O-Linked N-Acetylglucosamine Transferase (OGT). JOURNAL OF BIOLOGICAL CHEMISTRY 290:4801-4812(2015).
- Peternelj, TT; Marsh, SA; et al. Glutathione depletion and acute exercise increase O-GlcNAc protein modification in rat skeletal muscle. MOLECULAR AND CELLULAR BIOCHEMISTRY 400:265-275(2015).
Reviews
Q&As
The OGT-940H is a hot-selling enzymatically active protein. The specific activity is >25 pmol/min/μg which is measured by its ability to transfer GlcNAc from UDP-GclNAc to peptide OGT substrate.