OAZ1

  • Official Full Name

    ornithine decarboxylase antizyme 1

  • Overview

    Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation.

  • Synonyms

    OAZ1;ornithine decarboxylase antizyme 1;OAZ;antizyme 1;AZI;MGC138338;ODC-Az

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Chicken
  • Cynomolgus
  • Mammalian Cell
  • HEK293
  • E.coli
  • His
  • Non
  • His&Fc&Avi
  • GST

    Involved Pathway

    OAZ1 involved in several pathways and played different roles in them. We selected most pathways OAZ1 participated on our site, such as Aurora A signaling,Metabolism,Metabolism of amino acids and derivatives, which may be useful for your reference. Also, other proteins which involved in the same pathway with OAZ1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aurora A signaling TACC3,CENPA,TPX2,AURKAIP1,AURKB,GADD45A,TDRD7,TACC1,NDEL1
    Metabolism of amino acids and derivatives PAOX,AMDHD1,CTHL,UROC1,OAZ2B,OAZ3,IVD,AZIN2,DAO,SLC25A15
    Regulation of ornithine decarboxylase (ODC) OAZ1A,AZIN1B,AZIN1,AZIN1A,OAZ2B,OAZ3,OAZ2
    Metabolism ABCA1,AK7A,CYGB2,HAS1,LBR,ARL2BP,PROZA,PTPMT1,FAM96B,TM9SF1
    Metabolism of polyamines CKM,SLC25A15B,SAT1B,AZIN2,CKMT2,LSM1,SLC6A8,CKMT2A,OAZ3,SLC6A12
    Nucleotide Metabolism ADSL,MTHFD2,ADSS

    Protein Function

    OAZ1 has several biochemical functions, for example, ornithine decarboxylase inhibitor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OAZ1 itself. We selected most functions OAZ1 had, and list some proteins which have the same functions with OAZ1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding DLAT,DLL1,PRPF6,GABARAP,THRB,KDRL,PRNP,EIF2AK3,ATP6V0A2,TSSK6
    ornithine decarboxylase inhibitor activity OAZ3,OAZ2B,OAZ2A,OAZ2,OAZ1A

    Interacting Protein

    OAZ1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OAZ1 here. Most of them are supplied by our site. Hope this information will be useful for your research of OAZ1.

    EGFR;ATXN1;PIAS4;AZIN1;ODC1;RAB7A;PLXNA3;GBE1;CAMSAP2;TAF1B;GPATCH4;RNF20;PGM2L1;UPF1;LENG8;SRA1;CEPT1

    Resources

    References

    • Murakami, Y; Suzuki, J; et al. Developmental alterations in expression and subcellular localization of antizyme and antizyme inhibitor and their functional importance in the murine mammary gland. AMINO ACIDS 38:591-601(2010).
    • Svensson, KJ; Welch, JE; et al. Hypoxia-Mediated Induction of the Polyamine System Provides Opportunities for Tumor Growth Inhibition by Combined Targeting of Vascular Endothelial Growth Factor and Ornithine Decarboxylase. CANCER RESEARCH 68:9291-9301(2008).

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