NXF3
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Official Full Name
nuclear RNA export factor 3 -
Overview
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. -
Synonyms
NXF3;nuclear RNA export factor 3;TAPL-3;TAP-like protein 3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NXF3-1428H | Recombinant Human NXF3, GST-tagged | E.coli | Human | GST | N-term-303aa | |
| NXF3-1238HCL | Recombinant Human NXF3 cell lysate | Human | Non |
|
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| NXF3-2521H | Recombinant Human NXF3 Protein, His-tagged | E.coli | Human | His | Trp113-Val494 |
|
| NXF3-698H | Recombinant Human NXF3 Protein (1-531 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1-531 aa |
|
Involved Pathway
NXF3 involved in several pathways and played different roles in them. We selected most pathways NXF3 participated on our site, such as Ribosome biogenesis in eukaryotes,RNA transport,mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NXF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome biogenesis in eukaryotes | FBLL1,TCOF1,TBL3,REXO2,SMFN,CIRH1A,NOB1,NOP10,CSNK2A2A,RAN |
| Influenza A | KPNA2,HLA-DQB1,PIK3R3,HSPA8,PIK3R5,PRSS2,NFKBIA,IRAK4,PIK3CG,HSPA1A |
| RNA transport | THOC5,EIF4E1B,EIF2B4,PABPC4,DDX20,MAGOH,PNN,EIF5,RPP40,GEMIN6 |
| Herpes simplex infection | SRSF1B,GTF2I,EIF2AK3,CASP8,SOCS3B,IFNPHI1,TP53,SRSF7B,CLOCK,TAF5L |
| mRNA surveillance pathway | PPP2R5EB,BAT1,PABPC3,PABPC1,PPP1CAB,PPP2R5CB,GSPT2,DAZAP1,ALYREF,ETF1B |
Protein Function
NXF3 has several biochemical functions, for example, mRNA binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NXF3 itself. We selected most functions NXF3 had, and list some proteins which have the same functions with NXF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MPLKIP,ZNF238,FCRL4,TEX264,TRMT1,AKT1S1,ZFP746,ZFPM1,CCS,DYRK2 |
| nucleotide binding | MAP4K6,SLC27A4,NLRP9B,RBM47,MARF1,EIF4BB,EPHA4B,CPEB2,PTBP1,MKNK2B |
| poly(A) RNA binding | WDR43,FUS,CELF1,MAK16,C14orf166,ZFP326,EIF2AK2,TRAP1,DSP,TBRG4 |
| mRNA binding | RBFOX2,SRRM4,KHSRP,CALR,ITM2B,ADARB1,PAIP2,RPS26,CELF1,EIF4A3 |
Interacting Protein
NXF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NXF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NXF3.
NXT1;NXT2;SKIL
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References
- Katahira, J; Okuzaki, D; et al. Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I. NUCLEIC ACIDS RESEARCH 41:7060-7072(2013).
- Pezet-Valdez, M; Fernandez-Retana, J; et al. The 25 kDa Subunit of Cleavage Factor Im Is a RNA-Binding Protein That Interacts with the Poly(A) Polymerase in Entamoeba histolytica. PLOS ONE 8:-(2013).
