NXF1

  • Official Full Name

    nuclear RNA export factor 1

  • Overview

    This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants.

  • Synonyms

    NXF1;nuclear RNA export factor 1;DKFZp667O0311;Mex67;TAP;tip associating protein;mRNA export factor TAP;tip-associated protein;tip-associating protein

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
NXF1-1427H Recombinant Human NXF1, GST-tagged E.coli Human GST 42-346aa
NXF1-11014M Recombinant Mouse NXF1 Protein Mammalian Cells Mouse His
NXF1-4135R Recombinant Rat NXF1 Protein Mammalian Cells Rat His
NXF1-3622HCL Recombinant Human NXF1 293 Cell Lysate HEK293 Human Non
NXF1-1428H Recombinant Human NXF1 protein, His-tagged E.coli Human His 45-349 a.a.
NXF1-2519H Recombinant Human NXF1 Protein, His-tagged E.coli Human His Ala2-His198
NXF1-3796R Recombinant Rat NXF1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
NXF1-3796R-B Recombinant Rat NXF1 Protein Pre-coupled Magnetic Beads HEK293 Rat
Nxf1-406R Recombinant Rat Nxf1 Protein, His-tagged E.coli Rat His Ala2~Tyr197
NXF1-6285M Recombinant Mouse NXF1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
NXF1-6285M-B Recombinant Mouse NXF1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    NXF1 involved in several pathways and played different roles in them. We selected most pathways NXF1 participated on our site, such as Gene Expression,Herpes simplex infection,Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with NXF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transport of Mature Transcript to Cytoplasm SRSF11,SLBP,U2AF2,SFRS3A
    Gene Expression ZKSCAN5,DNMT3L,ZNF434,SMARCA5,ZNF224,ZIM3,U2AF2,ZNF668,EEF1G,TBX5A
    RNA transport PABPC4,EIF5,ELAC2,TRNT1,NXF3,RAE1,THOC2,XPOT,POM121L2,EIF4G3
    Influenza A GSK3B,FAS,ICAM1,HLA-DRA,HLA-DPB1,VDAC1,MAPK12,IL12A,IFNA16,TMPRSS4
    Herpes simplex infection C1QBP,NFKBIB,BF1,IRF9,HLA-G,TBPL1,HMGN1,CYCSB,PVRL1B,SRSF1B
    Processing of Capped Intron-Containing Pre-mRNA METTL3,TXNL4A,CD2BP2,TTC6,RNPC3,SNRNP48,ZCRB1,CSTF1,CSTF2,CCAR1
    Ribosome biogenesis in eukaryotes RCL1,CIRH1A,XRN1,REXO2,UTP6,RPP25,DROSHA,IMP4,RIOK2,NXF3

    Protein Function

    NXF1 has several biochemical functions, for example, nucleotide binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NXF1 itself. We selected most functions NXF1 had, and list some proteins which have the same functions with NXF1. You can find most of the proteins on our site.

    Function Related Protein
    nucleotide binding NSFA,SRSF4,PABPC4,MAPKAPK2B,SF3B14,TUBA2,ARF3B,PPIP5K2,UBE2NB,MYO7A
    protein binding GTF2H2,OGT,CEP57,C1orf116,GRB10,RAB1A,LMO3,DUSP26,ARHGEF40,DLX2
    single-stranded RNA binding LUZP4,HMGB1,A1CF,CBX7,STRBP,EIF2C3,HNRNPF,AGO3,LSM14A,RBMX
    poly(A) RNA binding WDR3,NOVA1,RRP8,MOV10,S100A16,HNRNPH1,SPATS2L,RPS3,CSTF1,SLC3A2

    Interacting Protein

    NXF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NXF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NXF1.

    NUP62;NXT1;NUP153;SRSF1

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