NUP50
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Official Full Name
nucleoporin 50kDa -
Overview
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
NUP50;nucleoporin 50kDa;NPAP60;NPAP60L;nuclear pore complex protein Nup50;nucleoporin Nup50;50 kDa nucleoporin;nuclear pore-associated protein 60L
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- T7
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
NUP50 involved in several pathways and played different roles in them. We selected most pathways NUP50 participated on our site, such as Antiviral mechanism by IFN-stimulated genes,Cell Cycle,Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUP50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antiviral mechanism by IFN-stimulated genes | DPF1,ARIH1L,IFIT10,EIF4E3,EIF4E,HERC5,ARIH1,UBE2L6,IFIT14,IFIT8 |
| Disease | KERA,OPN1MW2,TCEB3,ANTXR1,KPNA3,CPSF6,AP1G1,GPC5,CTBP2,RDBP |
| Cytokine Signaling in Immune system | PELI2,IFI27,TRIM38,FRS3,TRIM3,MX2,IFIT8,IFIT11,JAK3,TRIM8 |
| Cell Cycle, Mitotic | CDK5RAP2,NIPBLB,GORASP1,CEP76,MAU2,VRK1,OFD1,NCAPH2,ACTR1A,DYNC1H1 |
| Export of Viral Ribonucleoproteins from Nucleus | NUP35,NUPL2,DPF1 |
| Cellular responses to stress | TNIK,KDM6B,RB1CC1,HSBP1B,DPF1,MINK1,TERF2,HBXIP,CDKN2B,EGLN1B |
| Cellular response to heat stress | DNAJC7,MAPKAPK2B,C11orf73,BAG3,DPF1,DNAJC2,ST13,BAG5,DNAJB6,HSBP1B |
| Cell cycle | DBF4,HDAC6,PKMYT1,CNEP1R1,TUBGCP5,TP53,CDT1,ENSAA,CLSPN,BRE |
Protein Function
NUP50 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NUP50 itself. We selected most functions NUP50 had, and list some proteins which have the same functions with NUP50. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KPNA6,ALX1,CARD9,IGBP1,TSPAN2,SNTA1,LPA,HUWE1,PPP2R1A,TPD52L3 |
Interacting Protein
NUP50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUP50 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUP50.
KPNA1;KPNA4;KPNA5;KPNA6;KPNA2;KPNA2;KPNA2
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