NT5C3
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Official Full Name
5-nucleotidase, cytosolic III -
Overview
The pyrimidine 5-nucleotidase (P5N) includes type I and type II isozymes, which catalyze the dephosphorylation of the pyrimidine 5-monophosphates UMP and CMP to the corresponding nucleosides. This gene encodes the type I P5N isozyme and a gene on chromosome 17 encodes the type II P5N isozyme. Both genes are members of the nucleotidase gene family. Mutations in this gene are the main cause of P5N deficiency, which results in an autosomal recessive hemolytic anemia. It was reported that this gene had two pseudogenes on chromosomes 4 and 7, respectively, but the pseudogene on chromosome 7 is not verified. Alternatively spliced non-coding and coding transcript variants have been found for this gene. -
Synonyms
NT5C3;5-nucleotidase, cytosolic III;cytosolic 5-nucleotidase 3;cN III;P5N 1;PN I;PSN1;UMPH;UMPH1;cNIII;Cytosolic 5 nucleotidase 3;Cytosolic 5 nucleotidase III;p36;P5N1;PNI;Pyrimidine 5 nucleotidase 1;Uridine 5 monophosphate hydrolase 1;P5N-1;pyrimidine 5-nucleotidase 1;cytosolic 5-nucleotidase III;uridine 5-monophosphate hydrolase 1;PN-I;cN-III
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NT5C3 involved in several pathways and played different roles in them. We selected most pathways NT5C3 participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway,RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NT5C3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RIG-I-like receptor signaling pathway | ATG5,IFNPHI3,AZI2,RNF207B,TRAF3,Ifna15,DHX58,IKBKE,IFNA13,DDX58 |
| Jak-STAT signaling pathway | IL-15RA,PTPN11B,Ifnl2,PIK3R3B,IFNA13,IL7,Ifna11,PIAS1,M17,IFNG1-2 |
| Cytokine-cytokine receptor interaction | LIFRA,IFNK,CXCL12A,IL29,IFNA12,IL1R2,KDR,TNFSF13,IL4,TNFSF14 |
Protein Function
NT5C3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by NT5C3 itself. We selected most functions NT5C3 had, and list some proteins which have the same functions with NT5C3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
NT5C3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NT5C3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NT5C3.
Resources
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References
- Cheong, HS; Koh, Y; et al. NT5C3 polymorphisms and outcome of first induction chemotherapy in acute myeloid leukemia. PHARMACOGENETICS AND GENOMICS 24:436-441(2014).
- Monecke, T; Buschmann, J; et al. Crystal Structures of the Novel Cytosolic 5 '-Nucleotidase IIIB Explain Its Preference for m(7)GMP. PLOS ONE 9:-(2014).
