NSUN2
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Official Full Name
NOP2/Sun domain family, member 2 -
Overview
This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. -
Synonyms
NSUN2;NOP2/Sun domain family, member 2;NOL1/NOP2/Sun domain family 2 , NOL1/NOP2/Sun domain family, member 2;tRNA (cytosine(34)-C(5))-methyltransferase;FLJ20303;Misu;Myc induced SUN domain containing protein;TRM4;tRNA methyltransferase 4 homolog
Recombinant Proteins
- Zebrafish
- Mouse
- Chicken
- Human
- Mammalian Cells
- HEK293
- E.coli
- Insect Cells
- His
- Non
- N-StrepII and C-His
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NSUN2 involved in several pathways and played different roles in them. We selected most pathways NSUN2 participated on our site, such as Aurora B signaling,Gene Expression,tRNA modification in the nucleus and cytosol, which may be useful for your reference. Also, other proteins which involved in the same pathway with NSUN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| tRNA processing | QTRTD1,TRMT1,POP7,QTRT1,TRMT5,TSEN34,TSEN2,TYW1,XPOT,RPP14 |
| Gene Expression | NUDT21,ZNF18,ZNF75D,KHSRP,ADAT1,ZFP1,U2AF2,ADARB1A,SNAPC2,ZNF500 |
| tRNA modification in the nucleus and cytosol | MANEA,ADAT1,TYW5,QTRTD1,TRMT44,TYW3,LAGE3,QTRT1,TRMT112,TP53RK |
| Aurora B signaling | SGOL1,PEBP1,CDCA8,NDC80,KIF2C,NCAPH,CENPA,AURKB,KIF20A,SMC4 |
Protein Function
NSUN2 has several biochemical functions, for example, poly(A) RNA binding,tRNA (cytosine-5-)-methyltransferase activity,tRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NSUN2 itself. We selected most functions NSUN2 had, and list some proteins which have the same functions with NSUN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tRNA binding | TYW5,KARS,EIF2AK4,SSB,MADD,SEPSECS,AARSD1,YARS,ALKBH8,METTL1 |
| poly(A) RNA binding | ZCCHC24,ZNF638,ANP32A,ALDH6A1,IFI16,MCAT,HDGF,C1orf53,EIF2S1,NCL |
| tRNA (cytosine-5-)-methyltransferase activity | METTL21D,METTL8,PRDM13,RNMTL1A,FBLL1,METTL23,TRMT10C,NDUFAF5,PRDM12,DIMT1 |
Interacting Protein
NSUN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NSUN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NSUN2.
Cdk1;Tubg1;Plk1;Cep78;Dync1h1;argG;midostaurin;ssrna_ug;Srp72;NPM1;VCAM1
Resources
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References
- Martinez, FJ; Lee, JH; et al. Whole exome sequencing identifies a splicing mutation in NSUN2 as a cause of a Dubowitz-like syndrome. JOURNAL OF MEDICAL GENETICS 49:380-385(2012).
- Okamoto, M; Hirata, S; et al. Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers. DNA AND CELL BIOLOGY 31:660-671(2012).
