NSMCE2
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Official Full Name
non-SMC element 2, MMS21 homolog (S. cerevisiae) -
Overview
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. -
Synonyms
NSMCE2;non-SMC element 2, MMS21 homolog (S. cerevisiae);C8orf36, chromosome 8 open reading frame 36 , non SMC element 2 homolog (MMS21, S. cerevisiae);E3 SUMO-protein ligase NSE2;FLJ32440;MMS21;NSE2;C8orf36;hMMS21;hNSE2;methyl methanesulfonate sensitivity gene 21;MMS21 homolog;non-SMC element 2;Non-SMC element 2 homolog;Non-structural maintenance of chromosomes element 2 homolog;NSE2_HUMAN
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NSMCE2-1375H | Recombinant Human NSMCE2, GST-tagged | E.coli | Human | GST | 1-247aa | |
| NSMCE2-10916M | Recombinant Mouse NSMCE2 Protein | Mammalian Cells | Mouse | His |
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| NSMCE2-4095R | Recombinant Rat NSMCE2 Protein | Mammalian Cells | Rat | His |
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| NSMCE2-4861C | Recombinant Chicken NSMCE2 | Mammalian Cells | Chicken | His |
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| NSMCE2-3685HCL | Recombinant Human NSMCE2 293 Cell Lysate | HEK293 | Human | Non |
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| NSMCE2-3756R | Recombinant Rat NSMCE2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| NSMCE2-3756R-B | Recombinant Rat NSMCE2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| NSMCE2-6223M | Recombinant Mouse NSMCE2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NSMCE2-6223M-B | Recombinant Mouse NSMCE2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NSMCE2 involved in several pathways and played different roles in them. We selected most pathways NSMCE2 participated on our site, such as Metabolism of proteins,Post-translational protein modification,SUMO E3 ligases SUMOylate target proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with NSMCE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SUMO E3 ligases SUMOylate target proteins | CBX4,RING1,RNF2,SMC6,SCMH1,NSMCE4A,PHC2,CBX8,NSMCE1,SMC5 |
| SUMOylation | SENP5,NSMCE4A,RNF2,SMC6,EID3,SAE1,PHC1,CBX8,SMC5,PHC3 |
| SUMOylation of DNA damage response and repair proteins | EID3,CBX8,PHC3,PHC1,SMC5,SMC6,SCMH1,NSMCE4A,PHC2,NSMCE1 |
| Post-translational protein modification | DPAGT1,CBX4,YKT6,TRAPPC9,ADAMTS10,NAPAB,ARSE,EID3,MUC5AC,SUMF2 |
| Metabolism of proteins | CALCA,CTSH,ARSI,ALG14,SEC22A,ASNA1,ST6GAL2B,NAT8,SFTPBB,PFDN5 |
Protein Function
NSMCE2 has several biochemical functions, for example, SUMO transferase activity,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NSMCE2 itself. We selected most functions NSMCE2 had, and list some proteins which have the same functions with NSMCE2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | TRIM11,UBR7,RAG1,RNF149,CNOT4,CBLL1,RNF213,MID2,SIAH1,FANCL |
| zinc ion binding | ZSWIM7,RNF25,UBR5,LHX1B,NR1H3,DIDO1,ENPP2,RNF151,BMP1B,CHORDC1 |
| SUMO transferase activity | SUMO4,UBE2IA,MUL1,PIAS3,UBE2I,PIAS4,UBE2IB,TOPORS,SUMO1,CBX4 |
| protein binding | MYL7,GLRB,TBC1D22B,PSMC1,SOCS1,ALKBH4,PKP1,INPP5D,HIST1H3D,HIST2H3C |
Interacting Protein
NSMCE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NSMCE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NSMCE2.
SMC6;TXLNA;Smc6;NDNL2;SYNCRIP;Lck;ILK;Tgfbr1;SAMD1;NSMCE1;TM9SF4;SORT1;NIPSNAP1;Rbm8a
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References
- Dryden, NH; Broome, LR; et al. Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C. GENOME RESEARCH 24:1854-1868(2014).
- Chinen, Y; Sakamoto, N; et al. 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia. JOURNAL OF HEMATOLOGY & ONCOLOGY 7:-(2014).
