Nsf
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Official Full Name
N-ethylmaleimide-sensitive factor -
Overview
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. -
Synonyms
NSF;N-ethylmaleimide-sensitive factor;vesicle-fusing ATPase;N ethylmaleimide sensitive factor like protein;SKD2;NEM-sensitive fusion protein;vesicular-fusion protein NSF;N-ethylmaleimide-sensitive fusion protein;N-ethylmaleimide-sensitive factor-l
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- T7
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
Nsf involved in several pathways and played different roles in them. We selected most pathways Nsf participated on our site, such as Synaptic vesicle cycle,GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Nsf were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GABAergic synapse | GABRB2,GNAO1,GABRQ,GABRA4,GABRR3,GABARAPL2,PRKACB,GAD1,SLC38A2,GABRG1 |
| Synaptic vesicle cycle | ATP6V0A4,SLC17A6,SLC18A1,STX3,ATP6V0A1,SNAP25,DNM3,ATP6V1G1,STX1A,CPLX2 |
Protein Function
Nsf has several biochemical functions, for example, ATP binding,ATPase activity,ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by Nsf itself. We selected most functions Nsf had, and list some proteins which have the same functions with Nsf. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | GTF2F2A,DCAKD,PHKG2,MYO5B,UBE2KA,ACTR1B,RAD51L1,STK4,ATP6AP1,PIK3C2B |
| Rab GTPase binding | MICALL1,ZFP652,CCDC64,GAS8,CHML,STXBP5L,ODF2,ACAP2,RHOBTB3,MICALL2 |
| PDZ domain binding | PLEKHA1,CFTR,TGFBR3,LPAR2,SLC9A3R2,ARHGAP29,CRIPT,CCDC88C,LIN7C,FZD1 |
| protein binding | KIAA0146,SF3B4,UBR4,STXBP1,TTC23L,SMAD9,BECN1,TFAP2B,MTUS2,RHBDL1 |
| ATPase activity | ABCF1,ABCC1,ABCC5,ENTPD2,ABCA9,KIF7,KIF1B,WRNIP1,DNAH5,KIF3CB |
| syntaxin-1 binding | CCDC167,SLC6A4,STXBP1,LRRK2,STXBP2,UNC13A,CPLX1,VAMP2,STXBP3,SYT1 |
| ATPase activity, coupled | HSPA6,HSP104,VPS4A,HSPA1A,MYO1E,HSPA1B,CCT8,PEX1,MYH3,VPS4B |
| metal ion binding | LNX2B,ALOX5B.2,RNASEL,FHL2B,ZNF395,ZFP330,ZNF26,RHEB,ZIC4,CYP2AA9 |
| protein kinase binding | GSK3B,NEK6,TRIM5,LLGL1,CDK5RAP1,PTPN6,SLC12A4,C10orf46,MVP,CDK5RAP2 |
Interacting Protein
Nsf has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Nsf here. Most of them are supplied by our site. Hope this information will be useful for your research of Nsf.
GABBR2;NAPA;GABBR1;GRIA2;PTPN9;FES;PTPRC;FER;PTPRB;PTPRG;PTPN12;PTPRJ
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References
- Ramakrishnan, NA; Drescher, MJ; et al. Calcium Regulates Molecular Interactions of Otoferlin with Soluble NSF Attachment Protein Receptor ( SNARE) Proteins Required for Hair Cell Exocytosis*. JOURNAL OF BIOLOGICAL CHEMISTRY 289:8750-8766(2014).
- Rout, M; Senapati, MR; et al. Serosurveillance of foot-and-mouth disease in sheep and goat population of India. PREVENTIVE VETERINARY MEDICINE 113:273-277(2014).
