NRG2
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Official Full Name
neuregulin 2 -
Overview
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. -
Synonyms
NRG2;neuregulin 2;pro-neuregulin-2, membrane-bound isoform;divergent of neuregulin 1;Don 1;HRG2;neural and thymus derived activator for ErbB kinases;NTAK;Pro NRG2;pro-NRG2;OTTHUMP00000159546;OTTHUMP00000198728;OTTHUMP00000224194;OTTHUMP00000224196;OTTHUMP00000230686;divergent of neuregulin-1;neural- and thymus-derived activator for ErbB kinases;DON1
Recombinant Proteins
- Human
- Rat
- Mus musculus
- Wheat Germ
- E.coli
- Mammalian Cells
- Yeast
- HEK293
- In Vitro Cell Free System
- Non
- His
- Avi&Fc&His
- His&SUMO
Involved Pathway
NRG2 involved in several pathways and played different roles in them. We selected most pathways NRG2 participated on our site, such as ErbB signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | MYCB,PAK2B,PRKCB,GRB2B,PAK6,AKT2,ERBB4A,CAMK2A,MAPK3,MAP2K4 |
Protein Function
NRG2 has several biochemical functions, for example, growth factor activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRG2 itself. We selected most functions NRG2 had, and list some proteins which have the same functions with NRG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | HBEGFA,VEGFC,FGF10A,IL34,CECR1A,FGF6B,IL11,GDF10,GFER,PGF |
| receptor binding | F2RL1,PKD2,ASIP,MAG,Fgf15,CD86,RARRES2,FGF12B,CADM2A,PLA2G1B |
Interacting Protein
NRG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRG2.
Resources
Research Area
Diabetic Peripheral NeuropathyNeuronal Lineage Markers
Epidermal Growth Factor (EGF)
EGF Ligands
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References
