NR5A1
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Official Full Name
nuclear receptor subfamily 5, group A, member 1 -
Overview
The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008] -
Synonyms
NR5A1;nuclear receptor subfamily 5, group A, member 1;ELP;SF1;FTZ1;POF7;SF-1;AD4BP;FTZF1;SPGF8;SRXY3;steroidogenic factor 1;STF-1;nuclear receptor AdBP4;steroidogenic factor-1;adrenal 4 binding protein;adrenal 4-binding protein;fushi tarazu factor homolog 1;steroid hormone receptor Ad4BP;steroidogenic factor 1 nuclear receptor
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Mus musculus
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- Myc
- Avi
- Fc
- GST
Involved Pathway
NR5A1 involved in several pathways and played different roles in them. We selected most pathways NR5A1 participated on our site, such as Developmental Biology,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR5A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ovarian Infertility Genes | GJA4,SYNE2,ZP2,INHA,ZP3,MSH5,NRIP1,DMC1,DAZL |
| Developmental Biology | MED10,MED18,GDNF,SCN4A,SPTA1,CD24,HELZ2,COL6A1,NKX2.2A,TRPC5 |
| Transcriptional regulation of pluripotent stem cells | NR6A1,FOXD3,TDGF1,SALL4,POU5F3,LIN28A,HIF3A,PRDM14 |
| Generic Transcription Pathway | NR2F1,ZNF354B,MED6,ZNF599,ZNF496,ZNF446,NR4A2B,LRPPRC,ZNF713,ZNF583 |
| Wnt Signaling Pathway NetPath | SALL1,MARK2,SOX1,PAX2,TFAP2A,HIPK2,BRD7,CSNK2A1P,TAX1BP3,MAP1B |
| Gene Expression | HNRNPL,PRMT5,NR6A1A,HNRNPA0L,METTL3,ZNF747,CLP1,NELFE,SUDS3,CLNS1A |
| Nuclear Receptor transcription pathway | NRBP1,NRBF2,NR2F6,NR2F1,RARGA,PPARAA,NR2E3,NR2C1,NR6A1A,ESRRG |
| Nuclear Receptors | NR2C2,NR1H3,NR2E1,RARG,NR1I3,NR4A2A,NR2F1,NR1D2B,NR2F2,RARGB |
Protein Function
NR5A1 has several biochemical functions, for example, DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding,RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR5A1 itself. We selected most functions NR5A1 had, and list some proteins which have the same functions with NR5A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | GATA1A,POU4F2,NOC3L,Trl,BAHD1,SLC30A9,YBX1,ING5,PKN1,YBX2 |
| transcription coactivator activity | PARK7,TCERG1,MED1,NFKBIB,CITED2,BCL10,MED12,PRDM16,CTBP2,MED20 |
| RNA polymerase II distal enhancer sequence-specific DNA binding | MSC,ARX,NFE2L1,MEOX2,H2AFZ,NFE2L2,SFPI1,REL,NFKB1,SFPQ |
| protein binding | ZNF543,SH3BP2,SNRNP25,CSDC2,LIN7A,SUMO3,OLIG3,POLE4,TERF2,ALDH1A2 |
| transcription regulatory region sequence-specific DNA binding | SUV39H1,NFE2L2B,SIN3A,SUV39H2,SOX12,SFPQ,SOX4,NR5A1B,PSPC1,PER2 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | SRY,CEBPB,FOXC2,CREB1,SOX7,POU3F1,RELA,NFIX,MYF5,GLI1 |
| enzyme binding | ZFHX3,AXIN2,UGT1A4,CA,MST1R,YWHAH,TSPAN33,PRKCE,TRAF2,TULP3 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | RORAA,HNF4A,NR5A5,AHR2,NR1I3,NR1D2,NR6A1,PGR,PPARD,NR2F6B |
| steroid hormone receptor activity | RARB,RARGA,RORC,RORCB,NR1D2B,NR0B2,NR1D4A,RXRA,ESR2A,NR2F6 |
Interacting Protein
NR5A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR5A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR5A1.
NCK2;NR0B1;PNRC2;3bhs2_human_gene;FYN;NCK1;PIK3R1;CRK;GRB2;q7cfn3_yerpe;PROX1;cp11a_human_gene;star_human_gene;SMARCA5
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References
- Li, MH; Wu, FR; et al. Insulin-Like Growth Factor 3 Regulates Expression of Genes Encoding Steroidogenic Enzymes and Key Transcription Factors in the Nile Tilapia Gonad. BIOLOGY OF REPRODUCTION 86:-(2012).
- Sridevi, P; Chaitanya, RK; et al. FTZ-F1 and FOXL2 up-regulate catfish brain aromatase gene transcription by specific binding to the promoter motifs. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1819:57-66(2012).
- Yokoyama, C; Komatsu, T; et al. Generation of Rat Monoclonal Antibodies Specific for Ad4BP/SF-1. HYBRIDOMA 28:113-119(2009).
- Falender, AE; Lanz, R; et al. Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary. ENDOCRINOLOGY 144:3598-3610(2003).
