NR0B1
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Official Full Name
nuclear receptor subfamily 0, group B, member 1 -
Overview
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. -
Synonyms
NR0B1;nuclear receptor subfamily 0, group B, member 1;AHC, dosage sensitive sex reversal , DSS;nuclear receptor subfamily 0 group B member 1;AHCH;DAX1;nuclear receptor DAX1;nuclear receptor DAX-1;nuclear hormone receptor;DSS-AHC critical region
Recombinant Proteins
- Human
- Mouse
- Rat
- Rhesus macaque
- Zebrafish
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- T7
- Non
- DDK
- Myc
- Avi
- Fc
- GST
Involved Pathway
NR0B1 involved in several pathways and played different roles in them. We selected most pathways NR0B1 participated on our site, such as Gene Expression,Generic Transcription Pathway,Nuclear Receptor transcription pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR0B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | ZBTB8OS,DCP2,MED31,ZNF615,ZNF354B,ZNF718,ELAVL1,ELL,MTA1,NRBF2 |
| Generic Transcription Pathway | ZNF230,CDK8,ZNF493,NRBF2,MED31,ZNF100,ZIM3,NR2C2AP,ZNF599,CTGF |
| Regulation of Androgen receptor activity | SRY,SENP1,SPDEF,SMARCE1,SMARCA2,KAT7,APPBP2,NR2C1,NR2C2,GATA2 |
| Nuclear Receptors | NR2F1,RARG,NR4A2A,VDRB,RARGB,NR2C2,RORAA,NR1H3,NR1D2B,NR2E1 |
| Nuclear Receptor transcription pathway | RARGA,NR2E1,NR2C2AP,NR1I2,NR4A2B,RORAA,RXRBB,NR2F1,NR1I3,ESRRGA |
Protein Function
NR0B1 has several biochemical functions, for example, AF-2 domain binding,DNA binding,DNA hairpin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR0B1 itself. We selected most functions NR0B1 had, and list some proteins which have the same functions with NR0B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | RPS4Y1,ZMAT2,RBM4,HNRNPU,SAMD4,RNASEH2A,FAM120A,HNRNPD,SRP9,RPS7 |
| protein binding | SKI,WEE1,TTPA,VIM,LSM5,ZNF227,TXNRD3,PPP2R3C,PRCP,BAG2 |
| AF-2 domain binding | PPARGC1B,ESRRG |
| protein homodimerization activity | TREX1,SLC39A13,GTF2A2,ECT2,STUB1,CUBN,TYR,IKBKB,LRRK2,PTS |
| sequence-specific DNA binding | TEFB,NFIL3-3,HOXD11A,RX3,SIX4B,NKX2.2B,HIVEP2A,IRX5,HOXC6,SPIC |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | NR2E3,NR5A5,NR2F1B,AHR,PPARA,NR1I2,RORA,RORCB,NR2F6A,ESRRA |
| DNA binding | ENO1,ZNF554,RCOR2,ERCC6,HIST1H111R,RFX1A,HMGB2B,FOXA2,EEPD1,SOX1 |
| protein domain specific binding | SHC4,HMGB2,GABRR3,STRN4,LIN7B,NFASC,PKD1,HIST1H4E,YWHAH,ARHGEF4 |
| transcription corepressor activity | ATF5,ZEB1,CTCF,ATF7IP,LHX9,ZHX2,ENO1,TBL1XR1A,ATN1,YY1 |
Interacting Protein
NR0B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR0B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR0B1.
ESRRG;NR5A1;RORA
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