NPY1R
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Official Full Name
neuropeptide Y receptor Y1 -
Overview
Neuropeptide Y (NPY; MIM 162640) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits;a diverse range of important physiologic activities, including effects on psychomotor activity, food intake,;regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Two major;subtypes of NPY (Y1 and Y2) have been defined by pharmacologic criteria. NPY receptors, such as NPY1R, have been;identified in a variety of tissues, including brain, spleen, small intestine, kidney, testis, placenta, and aortic;smooth muscle (Herzog et al., 1992 (PubMed 1321422)). -
Synonyms
NPY1R;neuropeptide Y receptor Y1;NPYR;neuropeptide Y receptor type 1;NPY1-R
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Zebrafish
- Xenopus laevis
- Mus musculus
- Guinea pig
- Dog
- Sus scrofa (Pig)
- Rat
- Bovine
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Flag
- His&Fc&Avi
Involved Pathway
NPY1R involved in several pathways and played different roles in them. We selected most pathways NPY1R participated on our site, such as cAMP signaling pathway,Neuroactive ligand-receptor interaction,Regulation of lipolysis in adipocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPY1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | NPR1,HCN2,FSHB,GIPR,ATP2A2,SLC9A1,PRKACG,FFAR2,VIPR2,RRAS |
| Neuroactive ligand-receptor interaction | PTGER2,CALCR,TAAR14E,GLP1R,NR3C1,TAAR1,DRD4A,CHRNA2,C5AR1,SSTR4 |
| Regulation of lipolysis in adipocytes | INS2,Adcy4,PIK3CG,PIK3R1,PTGER3,GNAI1,PRKG2,IRS2,PDE3B,PIK3R3 |
Protein Function
NPY1R has several biochemical functions, for example, neuropeptide Y receptor activity,pancreatic polypeptide receptor activity,peptide YY receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NPY1R itself. We selected most functions NPY1R had, and list some proteins which have the same functions with NPY1R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SMARCD1,OTUD7B,FAM20C,BCL3,RNMT,NSF,RXFP1,MTIF3,PEG10,FBXO33 |
| peptide YY receptor activity | PPYR1,NPY5R,NPY2R |
| neuropeptide Y receptor activity | PRLHR,NPY8BR,QRFPR,PROKR2,PRLHR2A,PRLH2R,NPY5R,PROKR1,PRLHR2B,NPY2R |
| pancreatic polypeptide receptor activity | NPY8BR,PPYR1,NPY8AR,NPY5R |
Interacting Protein
NPY1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPY1R here. Most of them are supplied by our site. Hope this information will be useful for your research of NPY1R.
GALR2;NPY;PYY;ATP13A2;LSM7
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References
- Xiang, Q; Wang, CL; et al. Interaction of Somatostatin receptor-2 and Neuropeptide Y receptor-1 in mice dorsal root ganglion neurons on the Pinch-nerve injury model (Retracted article. See vol. 110, pg. 273, 2013). PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 105:71-75(2013).
- Singh, S; Metz, I; et al. Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons. ACTA NEUROPATHOLOGICA 125:595-608(2013).
