NPAS4
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Official Full Name
neuronal PAS domain protein 4 -
Overview
NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS);class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe;et al., 2004 (PubMed 14701734)). -
Synonyms
NPAS4;neuronal PAS domain protein 4;neuronal PAS domain-containing protein 4;bHLHe79;Le PAS;limbic enhanced PAS protein;PASD10;bHLH PAS type transcription factor NXF;Class E basic helix-loop-helix protein 79;HLH-PAS transcription factor NXF;Neuronal PAS4;NPAS4_HUMAN;NXF;PAS domain-containing protein 10;limbic-enhanced PAS protein;bHLH-PAS type transcription factor NXF;LE-PAS
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NPAS4-10805M | Recombinant Mouse NPAS4 Protein | Mammalian Cells | Mouse | His |
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| NPAS4-4036R | Recombinant Rat NPAS4 Protein | Mammalian Cells | Rat | His |
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| NPAS4-3695R | Recombinant Rat NPAS4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| NPAS4-3695R-B | Recombinant Rat NPAS4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| NPAS4-6017H | Recombinant Human NPAS4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| NPAS4-6150M | Recombinant Mouse NPAS4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NPAS4-6150M-B | Recombinant Mouse NPAS4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| NPAS4-6608HF | Recombinant Full Length Human NPAS4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 802 amino acids |
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Involved Pathway
NPAS4 involved in several pathways and played different roles in them. We selected most pathways NPAS4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NPAS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
NPAS4 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPAS4 itself. We selected most functions NPAS4 had, and list some proteins which have the same functions with NPAS4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXA2,BETA3,FOXO4,FOXL1,RELB,TAL1,ETV2,EF1,RUNX2,FOXI3A |
| DNA binding | HIST1H2BF,PBRM1,ZNF134,SIX4,ZNF224,THAP8,ZBTB26,HOXD9A,ZNF490,ZNF238 |
| protein heterodimerization activity | HIST1H2BF,YWHAH,PRSS28,ATF4,CABYR,GAD2,HYPM,UBA2,HGF,POLA1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | ZSCAN21,EBF1,CEBPE,NFYC,RELA,CEBPG,GABPA,MYOCD,HIF1A,PHOX2B |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ZNF664,PLAG1,MYBL2,MYC,KDM6A,FOXJ2,NKX6,HOXA2,PITX3,DLX5 |
| protein dimerization activity | NCF4,PEF1,NHLH2,LMLN,MYCS,PRKRIR,NCOA2,NCOA1,MNTB,ATOH1B |
| RNA polymerase II regulatory region DNA binding | PPARG,ATXN3L,NCOA1,TXK,NKX2-1 |
Interacting Protein
NPAS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPAS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPAS4.
Resources
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References
- Jaehne, EJ; Klaric, TS; et al. Effects of Npas4 deficiency on anxiety, depression-like, cognition and sociability behaviour. BEHAVIOURAL BRAIN RESEARCH 281:276-282(2015).
- Wang, D; Ren, M; et al. The Inhibitory Effects of Npas4 on Seizures in Pilocarpine-Induced Epileptic Rats. PLOS ONE 9:-(2014).
