NOX3
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Official Full Name
NADPH oxidase 3 -
Overview
This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009] -
Synonyms
NOX3;NADPH oxidase 3;MOX-2;GP91-3;gp91phox homolog 3;mitogenic oxidase 2;NADPH oxidase catalytic subunit-like 3
Recombinant Proteins
- Mouse
- Rat
- Human
- Mus musculus
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Avi
- Fc
- Non
Involved Pathway
NOX3 involved in several pathways and played different roles in them. We selected most pathways NOX3 participated on our site, such as HIF- signaling pathway,Phagosome,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF- signaling pathway | STAT3,PIK3R2,LDHA,ERBB2,PIK3CG,PLCG2,HK1,EGLN1,CUL2,HMOX1 |
| Osteoclast differentiation | MAPK1,SPI1,PLCG2,PIK3CB,cgr2b,TEC,PPP3CB,TREM2,MAP3K14,TYK2 |
| Phagosome | ATP6V0CA,TUBB2B,THBS2,TLR2-1,ATP6V0D2,SCARB1,RAB7A,HLA-DQA1,DYNC1LI2,ATP6V0A1B |
| Leukocyte transendothelial migration | ITGAL,JAM2,CLDN5,GNAI2,MAPK13,MYL10,ICAM1,GNAI3,PIK3CD,TXK |
Protein Function
NOX3 has several biochemical functions, for example, superoxide-generating NADPH oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NOX3 itself. We selected most functions NOX3 had, and list some proteins which have the same functions with NOX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| superoxide-generating NADPH oxidase activity | NOX4,PAX2,CYBB,SH3PXD2AA,NCF1,NOX5,NOX1 |
Interacting Protein
NOX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOX3.
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